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Effect of 3,4-Benzopyrene on Ultrastructure of Sinusoidal Cells of the Liver in Adult Male Rats

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Abstract

Reorganization of sinusoidal cells (endotheliocytes, Kupffer cells, and Ito cells) in the liver microregion of male rat liver exposed to 3,4-benzopyrene was studied. Synchronous activation of the lysosome-vacuole systems in Kupffer cells and endotheliocyte indicates cooperation of these cells in detoxification of benzopyrene and its metabolites. Ito cells lose lipid inclusions and actively proliferate; the appearance of intermediate forms between lipocytes and fibroblasts attests to activation of fibrogenesis in the liver.

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Authors and Affiliations

  1. Institute of Clinical and Experimental Lymphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk

    S. V. Michurina, S. I. Kolesnikov, S. V. Alisievich & I. Yu. Yushchenko

  2. Research Center of Medical Ecology, East-Siberian Research Center, Siberian Division of Russian Academy of Medical Sciences, Irkutsk

    S. V. Michurina, S. I. Kolesnikov, S. V. Alisievich & I. Yu. Yushchenko

Authors
  1. S. V. Michurina
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  2. S. I. Kolesnikov
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  3. S. V. Alisievich
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  4. I. Yu. Yushchenko
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Michurina, S.V., Kolesnikov, S.I., Alisievich, S.V. et al. Effect of 3,4-Benzopyrene on Ultrastructure of Sinusoidal Cells of the Liver in Adult Male Rats. Bulletin of Experimental Biology and Medicine 130, 1209–1211 (2000). https://doi.org/10.1023/A:1017500622380

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