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New Approach for Fluorescent Peptide Labeling with Pyrylium Cyanine Dyes

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Abstract

New approach for fluorescent peptide labeling with cyanine dyes utilizing the reaction of pyrylium salts with aliphatic aminogroup is proposed. The reaction of two pyrylium cyanines dye acids was investigated. Lysocyme was used as a model peptide for conjugation. The proposed method can be used as a simple and convenient alternative for the known procedures because it does not require preparation of the unstable amino-reactive intermediates from a carboxyl- or sulfo-derivative of cyanine dyes.

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REFERENCE

  1. S. Yarmoluk, O. Kostenko, and I. Dubey (2000) Bioorga. Medicinal Genetics, Chem. Lett., 10, 2201–2204.

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Authors and Affiliations

  1. Institute of Molecular Biology and Genetics NAS of Ukraine, 03143, 150 Zabolotnogo St., Kyiv, Ukraine

    O. M. Kostenko, S. Y. Dmitrieva & S. M. Yarmoluk

  2. Institute of Organic Chemistry, NAS of Ukraine, 5 Murmanska St., 02094, Kyiv, Ukraine

    O. I. Tolmachev

Authors
  1. O. M. Kostenko
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  2. S. Y. Dmitrieva
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  3. O. I. Tolmachev
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  4. S. M. Yarmoluk
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Correspondence to S. M. Yarmoluk.

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Kostenko, O.M., Dmitrieva, S.Y., Tolmachev, O.I. et al. New Approach for Fluorescent Peptide Labeling with Pyrylium Cyanine Dyes. Journal of Fluorescence 12, 173–175 (2002). https://doi.org/10.1023/A:1016844330051

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  • DOI: https://doi.org/10.1023/A:1016844330051

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