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Clinical Polymorphism of Shereshevsky–Turner Syndrome in Rostov Oblast and the Northern Caucasus in 1978–1998

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Abstract

Polymorphism of Shereshevsky–Turner syndrome (STS) was studied in 233 patients who were examined at medical genetic services of the Research Institute of Obstetrics and Pediatrics (Rostov-on-Don) and Rostov Regional Hospital from 1978 to 1998. The subjects examined were residents of the Rostov oblast (administrative region) (RO) and some settlements in the northern Caucasus (NC). The mean incidence rate of STS was 3.8 per 10 000 newborns in this region in the period studied. Most STS cases were accounted for by the X trisomy (60 and 66.6% in the RO and NC, respectively). The mosaic form of STS was found in 25% of cases in both RO and NC. Other cytogenetic forms were found in 13.5 and 8.33% of patients from the RO and NC, respectively. The clinical polymorphism of STS, dynamics of its manifestation during ontogeny, and anthropometric parameters of the patients were studied. The effects of the age of parents, the season and month of conception, occupational hazards at the parents' workplaces, and the place of residence on the risk of STS were analyzed. Factor analysis was used to determine the sets of the main clinical signs characteristic of different STS cytogenetic forms in the RO and NC populations.

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REFERENCES

  1. Zhang, S.Z., Xie, T., Tang, Y.C., and Zhang, S.Xu.Y., The Prevalence of Chromosome Diseases in the General Population of Sichuan, China, Clin. Genet., 1991, vol. 39, no. 2, pp. 81-88.

    Google Scholar 

  2. Bochkov, N.P., Klinicheskaya genetika (Clinical Genetics), Moscow: Meditsyna, 1997.

    Google Scholar 

  3. Gravholt, C.H., Juul, S., Naeraa, R.W., and Hansen, J., Morbidity in Turner Syndrome, J. Clin. Epidemiol., 1998, vol. 51, no. 2, pp. 147-158.

    Google Scholar 

  4. Lespinasse, J., Gicguel, C., Robert, M., and Le Bouc, Phenotypic and Genotypic Variability in Monozygotic Tripltes with Turner Syndrome, Clin. Genet., 1998, vol. 54, no. 1, pp. 56-59.

    Google Scholar 

  5. Park, J.P., Brothman, A.R., and Butler, M.G., Extensive Analysis of Mosaicism in a Case of Turner Syndrome, Arch. Path. Lab. Med., 1999, vol. 123, pp. 381-385.

    Google Scholar 

  6. Ogata, T. and Matsuo, N., Turner Syndrome and Female Sex-Chromosome Aberration Deduction of the Principal Factors Involved in the Development of Clinical Features, Hum. Genet., 1995, vol. 95, no. 6, pp. 607-629.

    Google Scholar 

  7. Moorchead, P., Nowell, P., and Mellman, W., Chromosome Preparation of Leukocytes Cultured from Human Peripheral Blood, Exp. Cell. Res., 1960, vol. 20, pp. 613-616.

    Google Scholar 

  8. Vladimirskii, B.M., Matematicheskie metody v biologii (Mathematical Methods in Biology), Rostovon-Don: Rostov. Gos. Univ., 1983.

    Google Scholar 

  9. Dimitru, I., Meikzhesku-Dzhordzhesku, M., Ratarum, M., et al., Fiziologiya i patofiziologiya vosproizvodstva cheloveka (Physiology and Pathophysiology of Human Reproduction), Bucharest, 1988, pp. 44-50.

  10. Kleczkowsska, A., Democh, E., Kubien, E., et al., Cytogenetic Findings in a Consecutive Series of 487 Patients with Turner Syndrome: The Leuven Experience, 1965–1989, Genet. Couns., 1990, vol. 1, pp. 227-233.

    Google Scholar 

  11. Nielsen, J. and Sillesen, I., Turner's Syndrome in 115 Danish Girls Born between 1995 and 1996, Acta Jutlandika, 1981, vol. 54, Medical Series 22.

  12. Davidenkova, E.F., Verlinskaya, D.K., and Mashkova, M.V., Structural Aberrations of the X Chromosome in Man, Hum. Genet., 1978, vol. 41, pp. 269-279.

    Google Scholar 

  13. Chuang, S.M., Lee, T.Y., Lin, S.J., and Jean, H.H., A Chromosomal Study of 864 Cases of Female Genital Abnormalities (Turner's Syndrome), J. Formosan Med. Assoc., 1985, vol. 84, pp. 1301-1312.

    Google Scholar 

  14. Morfologiya cheloveka. Uchebnoe posobie (Human Morphology: A Handbook), Nikityuk, B.A. and Chtetsov, V.P., Eds., Moscow: Mosk. Gos. Univ., 1990.

    Google Scholar 

  15. Ellison, J.W., Wardak, Z., Young, M.F., et al., PHOG, a Candidate Gene for Involvement in the Short Stature of Turner Syndrome, Hum. Mol. Genet., 1997, vol. 6, no. 8, pp. 1341-1347.

    Google Scholar 

  16. Kuleshov, N.P. and Simonyan, I.V., Estimation of Intergroup and Intragroup Similarity in Several Groups of Patients with Signs of Shereshevskii-Turner Syndrome and Sex Reversion, Biol. Zh. Armenii, 1988, vol. 41, no. 7, pp. 582-590.

    Google Scholar 

  17. Mazzanti, L. and Cacciari, E., Congenital Heart Disease in Patients with Turner's Syndrome, J. Pediatr., 1998, vol. 133, no. 5, pp. 688-692.

    Google Scholar 

  18. Lazyuk, G.I., Teratologiya cheloveka (Human Teratology), Moscow: Meditsyna, 1979.

    Google Scholar 

  19. Davidenkova, E.F. and Liberman, I.S., Klinicheskaya genetika (Clinical Genetics), Leningrad: Meditsyna, 1975.

    Google Scholar 

  20. Problemy meditsinskoi genetiki (Problems in Medical Genetics), Efroimson, V.P., Ed., Moscow: Meditsyna, 1970.

    Google Scholar 

  21. Vogel, F. and Motulsky, A.G., Human Genetics: Problems and Approaches, Heidelberg: Springer-Verlag, 1986, vol. 3.

    Google Scholar 

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Authors and Affiliations

  1. Research Institute of Biology, Rostov State University, Rostov-on-Don, 344090 Russia

    E. P. Guskov, T. P. Shkurat & A. Ya. Polienko

  2. Research Institute of Obstetrics and Pediatrics, Rostov State University, Rostov-on-Don, 344090, Russia

    S. S. Amelina, E. K. Timolyanova & S. V. Lomteva

  3. Research Institute of Neurocybernetics, Rostov State University, Rostov-on-Don, 344090, Russia

    B. V. Vladimirsky & B. B. Vladimirsky

Authors
  1. E. P. Guskov
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  2. T. P. Shkurat
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  3. A. Ya. Polienko
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  4. S. S. Amelina
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  5. E. K. Timolyanova
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  6. S. V. Lomteva
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  7. B. V. Vladimirsky
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  8. B. B. Vladimirsky
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Guskov, E.P., Shkurat, T.P., Polienko, A.Y. et al. Clinical Polymorphism of Shereshevsky–Turner Syndrome in Rostov Oblast and the Northern Caucasus in 1978–1998. Russian Journal of Genetics 37, 671–677 (2001). https://doi.org/10.1023/A:1016681426123

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  • DOI: https://doi.org/10.1023/A:1016681426123

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