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Effects of Populational Factors on Phospholipid Composition of Various Tissues in Natural Populations of the Tundra Vole Microtus oeconomus

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Abstract

The lipid composition of tissue membranes was studied in tundra voles at different phases of population cycle. At the period of depression of the volume of population, there were found a sharp rise of the content of lysophosphatidylcholine (LPC) in lipids of liver and spleen, the appearance of trace amounts of lysoforms in the brain tissue, and a reduction of portion of main fractions, particularly phosphatidylethanolamine (PE), in all studied tissues. It is at this period that the minimal content of more easily oxidizable fractions in phospholipids (PL) of all tissues was observed, with the maximal PC/PE ratio in lipids of liver and brain in most animal groups studied, which indicates the greatest rigidity of tissue membranes and minimal ability of lipids to oxidation. These particularities of the lipid fractional composition in vole tissues at different phases of population cycle are closely associated with the physiological state of the animals, specifically with their hormonal status depending on the population cycle phase, while elevation in the blood of stress-realizing hormones provides prerequisites for hyperactivation of peroxide oxidation of lipids (POL). The revealed pronounced changes of the tissue phospholipid composition in voles from natural populations at the depression of the population size can be considered as a part of non-specific reaction and associated intensification of POL processes.

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REFERENCES

  1. Zenkov, N.K. and Men'shchikova, E.B., Activated Oxygen Metabolites in Biological Systems, Usp. Sovrem. Biol., 1993, vol. 113, pp. 286–296.

    Google Scholar 

  2. Marcon, J.L. and Filcho, L.W., Antioxidant Processes of the Wild Tambaqui Colossoma macropomum (Osteichthyes, Serrasalmidae) from the Amazon, Comp. Biochem. Physiol., 1999, part C, vol. 123, pp. 257–263.

    Google Scholar 

  3. Kolosova, N.G., Shorin, Yu.P., and Kulikov, V.Yu., POL Response in Rat Liver and Lungs at a Long-Term Cold Adaptation, Byull. Eksp. Biol. Med., 1981, vol. 91, pp. 436–437.

    Google Scholar 

  4. Mkhitaryan, V.G., Agadzhanov, M.I., and Gevarkyan, D.M., Enzyme Mechanisms of the Cell Antiradical Protection at Extreme States, Vest. Akad. Med. Nauk USSR, 1982, no. 9, pp. 15–19.

  5. Ostrovskaya, L.K., Superoxide Radical in Deficit of Metals and Symptoms of Chlorosis, Fiziol. Biokhim. Kult. Rast., 1993, vol. 25, pp. 107–113.

    Google Scholar 

  6. Burlakova, E.B., Gubareva, A.E., Arkhipova, G.V., and Rachinskii, V.A., Modulation of Lipid Peroxide Oxidation by Biogenic Amines in Model Systems, Vopr. Med. Khim., 1992, vol. 32, no. 2, pp. 17–20.

    Google Scholar 

  7. Chernyshev, V.I., Etiology and Prevention of Free Radical Pathology at Physiological Fish Adaptation to Conditions not Peculiar to Ecology of This Species, Bioantiokisliteli v regulyatsii metabolizma v norme i patologii (Bioantioxidants in Metabolism Regulation in Norm and Pathology), Moscow, 1982, pp. 141–150.

  8. Baroboi, V.A., Mechanisms of Stress and POL, Usp. Sovr. Biol., 1991, vol. 111, pp. 922–930.

    Google Scholar 

  9. Polivoda, B.I., Konev, V.V., and Kruglikov, A.P., K+-Dependent Swelling of Ehrlich Ascites Carcinoma Cells in the Presence of Hydroperoxides of Lipolic Acid and Fe2+ Ions, Biofizika, 1981, vol. 26, pp. 675–677.

    Google Scholar 

  10. Keeps, T.V., Effect of Gamma-Iirradiation on Peroxidation of Lipids and Physical Properties of Cell Nuclear Membrane Structures, Cand. Sci. Diss., Tallinn, 1983.

  11. Tyurin, V.A., Arduini, A., Tyurina, Yu.Yu., Sokolova, T.V., Furaev, V.V., Rychkova, M.P., and Arrigoni-Martelli, E., Reparation of Membrane Lipid Bilayer at Oxidative Stress: Reacylation of Phosphatidylethanoamine in Membranes of Synaptosomes, Photoreceptors, and Erythrocytes, Zh. Evol. Biokhim. Fiziol., 1996, vol. 32, pp. 248–255.

    Google Scholar 

  12. Kreps, E.M., Tyurin, V.A., Chelomin, V.P., Gorbunov, N.V., Nalivaeva, N.N., Tyurina, Yu.Yu., Avrova, N.F., and Kagan, V.E., Mechanisms of Initiation of Lipid Peroxidation in Synaptosomes of Marine Teleosts, Zh. Evol. Biokhim. Fiziol., 1987, vol. 23, pp. 461–467.

    Google Scholar 

  13. Burlakova, Ye.V., Palmina, N.P., and Maltseva, Ye.L., A Physico-Chemical System Regulating Lipid Peroxidation in Biomembranes during Tumor Growth, Membrane Lipids, Vigo-Pelfrei, C., Ed., Boston: Boca Raton, Ann Arbor, 1991, vol. 3, pp. 209–237.

  14. Aristarkhova, S.A., Burlakova, E.B., Gvakhariya, V.O., et al., The Regulatory Role of Interconnected Changes of Antioxidant Concentrations in Lipids of Cell Membranes, Dokl. Akad. Nauk SSSR, 1976, vol. 228, pp. 215–218.

    Google Scholar 

  15. Burlakova, E.B., Arkhipova, G.V., Goloshchapov, A.N., Molochkina, E.M., and Khokhlov, A.P., Membrane Lipids as Information Transmitters, Bioantiokisliteli v regulyatsii metabolizma v norme i patologii (Bioantioxidants in Regulation of Metabolism in Norm and Pathology), Moscow, 1982, pp. 74–83.

  16. Badzhinyan, S.A., Kazaryan, P.A., Akaev, S.E., and Saaryan, A.V., Changes of Structural-Functional Properties of Erythrocyte Membranes, Radiobiol. Radioecol., 1995, vol. 35, pp. 364–369.

    Google Scholar 

  17. Klimov, A.N., Lipidy, lipoproteidy i ateroskleroz (Lipids, Lipoproteins, and Arteriosclerosis), St. Petersburg, 1995.

  18. Burlakova, E.B., Molecular Mechanisms of Effects of Antioxidants at Treatment of Cardiovascular Diseases, Kardiol., 1980, no. 8, pp. 48–52.

  19. Varshavskii, S.N. and Krylova, K.T., Fundamental Principles of Estimation of Age in Mouse Rodents. I. Mice: Data on Rodents, Fauna i ekologiya gryzunov (Fauna and Ecology of Rodents), Moscow, 1948, no. 3, pp. 179–190.

  20. Pyastolova, O. A., Ecological-Morphological Particularities of Sub-Arctic Populations of Field-Vole, Cand. Sci. Diss., Sverdlovsk, 1967.

  21. Maslova, K.I., On the Role of Histological Method in Performing Radio-Ecological Studies, Metody radioekologicheskikh issledovanii (Methods of Radio-Ecological Studies), Moscow, 1971, pp. 155–160.

  22. Keits, M., Tekhnika lipidologii (Technique of Lipidology), Moscow, 1975.

  23. Higgins, J.A., Biologicheskie membrany (Biological Membranes), Moscow, 1990.

  24. Suslikov, V.I., On Reduction of Mortality of Mammals from Intestinal Syndrome at a Partial Shielding of Bone Marrow or after Post-Radiation Transplantation of Bone Marrow, Radiobiol., 1973, vol. 13, pp. 880–888.

    Google Scholar 

  25. Oimatov, M., Shakarbaev, E.B., Zaitova, F.Z., Azizov, A.A., Tarasov, V.A., and Azimov, D.A., Phospholipids and their Fatty Acid Composition in Liver Homogenates of the Mollusc Lymnaea auricularia Invaded by Partenitae of Trematode Orientobilharzia turkestanica, Zh. Evol. Biokhim. Fiziol., 1996, vol. 32, pp. 256–260.

    Google Scholar 

  26. Suvorova, L.A., Korolev, A.B., and Shalaev, S.V., Lipids of Blood Plasma and Platelets in Patients with Primary Angina Pectoris and Chronic Heart Disease, Vopr. Med. Khim., 1990, vol. 36, no. 4, pp. 24–28.

    Google Scholar 

  27. Gribanov, G.A., Structural Peculiarities and Biological Role of Lysophospholipids, Vopr. Med. Khim., 1991, vol. 37, no. 4, pp. 2–10.

    Google Scholar 

  28. Arkhipova, G.V. and Shishkina, L.N., Change of Antioxidant Properties and Membrane Lipid Composition at Irradiation, Informats. Byull., Radiobiol., 1975, no. 18, pp. 124–128.

  29. Kudyasheva, A.G., Shishkina, L.N., Zagorskaya, N.G., and Taskaev, A.I., Effect of Technogenic Pollution on Regulatory Cell Systems, Seriya preprintov., Nauchnye doklady., Komi nauchnyi tsentr Ural. Otdel. Akad. Nauk SSSR, 1990, no. 248.

  30. Kudyasheva, A.G., Shishkina, L.N., Zagorskaya, N.G., and Taskaev, A.I., Biokhimicheskie mekhanizmy radiatsionnogo porazheniya prirodnykh populyatsii myshevidnykh gryzunov (Biochemical Mechanisms of Radiation Damage of Natural Populations of Mouse Rodents), St. Petersburg, 1997.

  31. Gichev, Yu.P., Pechen.: adaptatsiya, ekologiya (The Liver: Adaptation, Ecology), Novosibirsk, 1993.

  32. Shevchenko, O.G., The Tissue Phospholipid Composition in Tundra Voles Living under Conditions of Elevated Natural Radioactivity, Vozdeistvie radioaktivnykh zagryaznenii na nazemnye ekosystemy v zone avarii na Chernobyl.skoi AES (1986.1996) (Effect of Radioactive Pollutions on Terrestrial Ecosystems in the Region of the Chernobyl AES Accident (1986.1996)), Syktyvkar, 1996, pp. 123–131.

  33. Dolgikh, V.T., Effect of Acute Lethal Hemorrhage on Post-Reanimation Changes in Heart Phospholipids and Their Prevention, Vopr. Med. Khim., 1991, vol. 37, no. 3, pp. 9–13.

    Google Scholar 

  34. Shevchenko, O.G., Zagorskaya, N.G., Kudyasheva, A.G., and Shishkina, L.N., On Some Peculiarities of Regulation of the Antioxidant System in Wild Species of Mouse Rodents, Ekolog., 1999, no. 1, pp. 73–76.

  35. Ermakova, O.V., Morpho-Functional Changes in Thyroid Gland and Adrenal Cortex in Tundra Voles Living under Conditions of Elevated Radioactivity, Cand. Sci. Diss., Kiev, 1991.

  36. Sel'ye, H., Ocherki ob adaptatsionnom syndrome (Essays on Adaptive Syndrome), Moscow, 1960.

  37. Tkachev, A.V., The Role of Neuroendocrine Factors in Self-Regulation of Population Density, Ekolog., 1976, no. 2, pp. 30–36.

  38. Nikolaev, V.I., Denisenko, N.P., and Nikolaeva, N.V., Change of Lipid Peroxidation Dependung on Hormonal Responses at a Prolonged Electrostimulation of Rabbit Dorso-Medial Hypothalamic Nuclei, Vopr. Med. Khim., 1995, vol. 41, no. 6, pp. 33–36.

    Google Scholar 

  39. Grigor'ev, Yu.G. and Shafirkin, A.V., Change of Stability of the Organism in the Course of Continuous External Low-Dose Intensity Gamma-Irradiation, I Vsesoyuznyi simpozium. Molekulyarno-kletochnye mekhanizmy khronicheskogo (vneshnego i vnutrennego) deistviya ioniziruyushchego izlucheniya na biologicheskie sistemy. (I All-Union Symposium. Molecular-Cellular Mechanisms of Chronic (External and Internal) Action of Irradiation on Biological Systems.), Pushchino, 1990, pp. 37–38.

  40. Kulagina, T.P., Activation of Lipid Metabolism in Nuclei and Chromatin of Thymocytes of Rats Subjected to Long Low-Dose Intensity Gamma-Irradiation, Biokhim., 1997, vol. 62, pp. 1206–1211.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Biology, Komi Research Center, Ural Division, Russian Academy of Sciences, Syktyvkar, Russia

    O. G. Shevchenko & A. G. Kudyasheva

  2. Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    L. N. Shishkina

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  1. O. G. Shevchenko
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  2. L. N. Shishkina
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  3. A. G. Kudyasheva
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Shevchenko, O.G., Shishkina, L.N. & Kudyasheva, A.G. Effects of Populational Factors on Phospholipid Composition of Various Tissues in Natural Populations of the Tundra Vole Microtus oeconomus . Journal of Evolutionary Biochemistry and Physiology 38, 169–175 (2002). https://doi.org/10.1023/A:1016554320190

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