Abstract
Multilayered liposome (MLV) formation from water/organic-solvent (W/O) emulsions was studied. A fundamental liposome population parameter, the Eratio, was defined and used to estimate the bilayer number and water spacing in MLV liposomes. MLVs prepared from W/O emulsions have optimum drug entrapment at an emulsion-lipid/emulsion-water ratio of ∼0.33. Drug entrapment is typically 50 to 65% under these optimal conditions.
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Pidgeon, C., Hunt, A.H. & Dittrich, K. Formation of Multilayered Vesicles from Water/Organic-Solvent (W/O) Emulsions: Theory and Practice. Pharm Res 3, 23–34 (1986). https://doi.org/10.1023/A:1016316730560
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DOI: https://doi.org/10.1023/A:1016316730560