Skip to main content
Log in

Determination of Allopurinol and Oxypurinol in Rat Plasma, Intestinal Wash, and Bile by High-Performance Liquid Chromatography with Electrochemical Detection (HPLC/EC) Following Automated Solid Phase Extraction

  • Note
  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

REFERENCES

  1. T. F. Yu and A. B. Gutman. Effect of allopurinol (4-hydroxypyrazolo-(3,4-d)pyrimidine) on serum and urinary uric acid in primary and secondary gout. Am. J. Med. 37:885–891 (1964).

    Google Scholar 

  2. R. W. Rundles, E. N. Metz, and H. R. Silberman. Allopurinol in the treatment of gout. Ann. Intern. Med. 64 (2):229–258 (1966).

    Google Scholar 

  3. P. Conzentino, E. J. Eisenberg, G. G. Liversidge, and K. C. Cundy. In situ rat model for simultaneous determination of intestinal absorption, hepatic extraction and biliary excretion. Pharm. Res. 6(Suppl.):113 (1989).

    Google Scholar 

  4. C. T. Hung, A. R. Zoest, and D. G. Perrier. Analysis of allopurinol and oxypurinol in plasma by reversed-phase HPLC. J. Liq. Chromatogr. 9 (11):2471–2483 (1986).

    Google Scholar 

  5. J. M. Failler, R. Farinotti, and A. Dauphin. Quantitative liquid chromatography of allopurinol and oxypurinol in human plasma and urine. Ther. Drug Monitor. 7 (3):324–328 (1985).

    Google Scholar 

  6. F. Palmisano, E. Desimoni, and P. G. Zambonin. High-performance liquid chromatography with polarographic and voltammetric anodic detection: Simultaneous determination of allopurinol, oxypurinol and uric acid in body fluids. J. Chromatogr. 306:205–214 (1984).

    Google Scholar 

  7. H. Breithaupt and G. Goebel. Determination of allopurinol and oxypurinol in biological fluids by high-performance liquid chromatography. J. Chromatogr. 226:237–242 (1981).

    Google Scholar 

  8. R. Boulieu, C. Bory, P. Baltassat, and C. Gonnet. Simultaneous determination of allopurinol, oxypurinol, hypoxanthine and xanthine in biological fluids by high-performance liquid chromatography. J. Chromatogr. Biomed. Appl. 307:469–474 (1984).

    Google Scholar 

  9. R. A. Hartwick, D. V. Haverbeke, M. McKeag, and P. R. Brown. Sample preparation techniques prior to HPLC analysis of serum nucleosides and their bases. J. Liq. Chromatogr. 2 (5):725–744 (1979).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eisenberg, E.J., Conzentino, P., Liversidge, G.G. et al. Determination of Allopurinol and Oxypurinol in Rat Plasma, Intestinal Wash, and Bile by High-Performance Liquid Chromatography with Electrochemical Detection (HPLC/EC) Following Automated Solid Phase Extraction. Pharm Res 8, 653–655 (1991). https://doi.org/10.1023/A:1015821210841

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1015821210841

Navigation