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The Effect of Food on the Absorption of Controlled-Release Theophylline in Mini-Swine

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Abstract

The effect of differing fat contents of food on the bioavailability of theophylline following a 400-mg single dose of Theo-24 was studied in mini-swine. The pharmacokinetics of theophylline, following the intravenous administration of aminophylline equivalent to 5 mg/kg as a single dose, were also studied in the same animals. The terminal plasma half-life of theophylline following an i.v. dose was found to be approximately 24 hr. The volume of distribution, V dext, and clearance following the i.v. dose were approximately 0.7 liter/kg and 0.023 liter/hr/kg, respectively. The terminal half-life of theophylline following the administration of theophylline capsules under fasting conditions was 21 hr. The average bioavailability under fasting conditions was approximately 80% compared to the i.v. dose. Food appeared to have decreased the rate of absorption but no significant effect on the extent of absorption.

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REFERENCES

  1. L. Hendeles, R. P. Iafrate, and M. Weinberger. Clin. Pharmacokinet. 9:95–135 (1984).

    Google Scholar 

  2. M. Lagas and J. H. G. Jonkman. Eur. J. Clin. Pharmacol. 24:761–767 (1983).

    Google Scholar 

  3. L. Vaughan, G. Milavetz, M. Hill, M. Weinberger, and L. Hendeles. Drug Intell. Clin. Pharm. 18:510 (1984).

    Google Scholar 

  4. A. Karim, T. Burns, L. Wearley, J. Streicher, and M. Palmer. Clin. Pharmacol. Ther. 38:77–83 (1985).

    Google Scholar 

  5. S. Pedersen. Br. J. Clin. Pharmacol. 12:904–905 (1981).

    Google Scholar 

  6. M. A. Osman, R. B. Patel, D. S. Irwin, and P. G. Welling. Biopharm. Drug Disp. 4:63–72 (1983).

    Google Scholar 

  7. S. Pedersen and J. Moller-Petersen. J. Pediat. 74:534–538 (1984).

    Google Scholar 

  8. G. D. Koritz, D. W. A. Bourne, J. P. Hunt, V. K. Prasad, R. F. Bevill, and S. R. Gautam. J. Vet. Pharmacol. Ther. 4:233–239 (1981).

    Google Scholar 

  9. J. G. Wagner and E. Nelson. J. Pharm. Sci. 52:610–611 (1963).

    Google Scholar 

  10. M. Gibaldi and D. Perrier. In J. Swarbrick (ed.), Pharmacokinetics, Marcel Dekker, New York, 1975, p. 148.

    Google Scholar 

  11. L. A. Bauer, M. Gibaldi, and R. E. Vestal. Clin. Pharmacokin. 9:184–187 (1984).

    Google Scholar 

  12. P. G. Welling, L. L. Lyons, W. A. Craig, and G. A. Trochta. Clin. Pharmacol. Ther. 17:475–480 (1975).

    Google Scholar 

  13. S. H. D. Jackson, C A. P. Cooper, and T. H. Turner. Eur. J. Clin. Pharmacol. 28:429–431 (1985).

    Google Scholar 

  14. L. Hendeles, M. Weinberger, G. Milavetz, M. Hill, III, and L. Vaughan. Chest 87:758–765 (1985).

    Google Scholar 

  15. M. Weinberger. Pharmacotherapy 4:181–198 (1984).

    Google Scholar 

  16. N. H. Leeds, P. Gal, A. A. Purohit, et al. J. Clin Pharmacol. 22:196–200 (1982).

    Google Scholar 

  17. A. Karim, T. Burns, D. Janky, and A. Hurwitz. Clin. Pharmacol. Ther. 38:642–647 (1985).

    Google Scholar 

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Authors and Affiliations

  1. Biopharmaceutics Reseach Branch, Food and Drug Administration, Washington, D.C, 20204

    Gerald K. Shiu

  2. Metabolism Branch, Food and Drug Administration, Beltsville Research Facility, Beltsville, Maryland, 20811

    Arlen O. Sager

  3. Biopharmaceutics Division, Food and Drug Administration, 5600 Fisher Lane, Rockville, Maryland, 20857

    Raja B. Velagapudi & Jerome P. Skelly

  4. IDR Inc, Rockville, Maryland, 20855

    Vadlamani K. Prasad

Authors
  1. Gerald K. Shiu
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  2. Arlen O. Sager
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  3. Raja B. Velagapudi
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  4. Vadlamani K. Prasad
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  5. Jerome P. Skelly
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Shiu, G.K., Sager, A.O., Velagapudi, R.B. et al. The Effect of Food on the Absorption of Controlled-Release Theophylline in Mini-Swine. Pharm Res 5, 48–52 (1988). https://doi.org/10.1023/A:1015815528975

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