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Generation of Reactive Oxygen Species by Mitochondria in Senescence-Accelerated OXYS Rats

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Abstract

Chemiluminescence assay showed that oxygen reduction and production of superoxide anion and hydrogen peroxide by liver mitochondria in OXYS rats highly sensitive to oxidative stress were less intensive than in Wistar rats. Experiments with cytochrome c oxidase inhibitors showed that decreased O2 - generation in mitochondria of OXYS rats is probably associated with changes in complex III of the electron transport chain.

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Authors and Affiliations

  1. Research Center for Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Russia

    E. B. Men'shchikova, I. G. Shabalina, N. K. Zenkov & N. G. Kolosova

  2. Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Russia

    E. B. Men'shchikova, I. G. Shabalina, N. K. Zenkov & N. G. Kolosova

  3. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    E. B. Men'shchikova, I. G. Shabalina, N. K. Zenkov & N. G. Kolosova

Authors
  1. E. B. Men'shchikova
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  2. I. G. Shabalina
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  3. N. K. Zenkov
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  4. N. G. Kolosova
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Men'shchikova, E.B., Shabalina, I.G., Zenkov, N.K. et al. Generation of Reactive Oxygen Species by Mitochondria in Senescence-Accelerated OXYS Rats. Bulletin of Experimental Biology and Medicine 133, 175–177 (2002). https://doi.org/10.1023/A:1015559124601

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  • DOI: https://doi.org/10.1023/A:1015559124601

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