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Effects of Type 1A Serotonin Receptor Agonist 8-OH-DPAT on Immune Response

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Abstract

The selective agonist of type 1 A serotonin receptors 8-hydroxy-2-(di-n-propyl-amino)tetra-lin (8-OH-DPAT) suppressed the immune response. Intraperitoneal administration of 1 mg/kg 8-OH-DPAT to Wistar rats over 2 days after immunization decreased the count of plaque- and rosette-forming cells on day 5. Our results indicate that type 1A serotonin receptors are involved in the realization of the immunosuppressive effects of the serotoninergic system.

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Authors and Affiliations

  1. Laboratory of Mechanisms of Neurochemical Modulation, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    G. V. Idova, M. A. Cheido, E. N. Zhukova, E. L. Al'perina & L. V. Devoino

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  1. G. V. Idova
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  2. M. A. Cheido
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  3. E. N. Zhukova
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  4. E. L. Al'perina
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  5. L. V. Devoino
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Idova, G.V., Cheido, M.A., Zhukova, E.N. et al. Effects of Type 1A Serotonin Receptor Agonist 8-OH-DPAT on Immune Response. Bulletin of Experimental Biology and Medicine 132, 981–983 (2001). https://doi.org/10.1023/A:1013627613769

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  • DOI: https://doi.org/10.1023/A:1013627613769

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