Abstract
Choline and N,N-dimethylaminoethyl esters of arachidonic and some other fatty acids were synthesized. Experiments on the embryos and larvae of sea urchins, sensitive to cholinergic compounds, showed that arachidonoylcholine exhibited cholinomimetic activity similar to that of nicotine while N,N-dimethylaminoethyl arachidonate acted as acetylcholine antagonist. The corresponding esters of docosahexaenoic acid were found to manifest similar biological properties.
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Bezuglov, V.V., Zinchenko, G.N., Nikitina, L.A. et al. Arachidonoylcholine and N,N-Dimethylaminoethyl Arachidonate, New Cholinergic Compounds. Russian Journal of Bioorganic Chemistry 27, 200–203 (2001). https://doi.org/10.1023/A:1011341623358
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DOI: https://doi.org/10.1023/A:1011341623358