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Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes

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Abstract

Ruthenium catalyzed ring opening cross-metathesis of resin-bound bicyclic alkenes with terminal aryl olefins was utilized for the construction of a combinatorial library containing highly functionalized cyclopentane derivatives. The technology described herein represents a convergent method for the diastereospecific synthesis of unique cyclopentane molecular scaffolds useful for exploratory medicinal chemistry.

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Authors and Affiliations

  1. Sepracor Inc., 111 Locke Dr., Marlborough, MA, 01752-7231, U.S.A

    Jingrong Cao, Gregory D. Cuny & James R. Hauske

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  1. Jingrong Cao
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  2. Gregory D. Cuny
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  3. James R. Hauske
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Cao, J., Cuny, G.D. & Hauske, J.R. Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes. Mol Divers 3, 173–179 (1997). https://doi.org/10.1023/A:1009663720800

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  • DOI: https://doi.org/10.1023/A:1009663720800

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