Skip to main content
Log in

Infectious Complications of Combination Anticancer Chemotherapy for Urogenital Cancers

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

We reviewed the infectious complications in 207 courses of anticancer chemotherapy to 93 patients with urogenital cancer. Thirty episodes (14.5%) of neutropenic fever containing 9 cases (4.3%) of infection were observed. Five patients (16.7%) had pyelonephritis, one (3.3%) had acute prostatitis, two (6.6%) had pneumonia and one (3.3%) had bacteraemia. Multivariate analysis revealed that the infectious complications during anticancer chemotherapy were mainly associated with urinary diversion, hydronephrosis and duration of severe neutropenia (<500/mm3).

These results suggest that infectious complications should be prevented in patients with urinary diversion, hydronephrosis and severe neutropenia during anticancer chemotherapy for urogenital cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Pizzo, P. A.: Granulocytopenia and cancer therapy: Past problems, current solutions, future challenge. Cancer, 54, 2649 (1984).

    PubMed  Google Scholar 

  2. Sculier, J. P., Wheets, D., Klastersky, J.: Causes of death in febrile granulocytopenic cancer patients receiving empiric antibiotic therapy. Eur. J. Cancer Clin. Oncol., 20, 55 (1984).

    PubMed  Google Scholar 

  3. Naito, S., Kuroiwa, T., Ueda, T. et al.: Combination chemotherapy with intra-arterial cisplatin and doxorubicin plus intravenous methotrexate and vincristine for local advanced bladder cancer. J. Urol., 154, 1704 (1995).

    PubMed  Google Scholar 

  4. Philoppt-Howard, J.: Infections in neutropenic patients. Curr. Opin. Infect. Dis., 8, 234 (1995).

    Google Scholar 

  5. Bodey, G. P., Buckley, M., Sathe, T. S. et al.: Quantitative relationship between circulating leukocytes and infection in patients with acute leukemia. Ann. Intern. Med., 64, 328 (1966).

    PubMed  Google Scholar 

  6. Ito, Y., Komeda, H., Saitoh, A. et al.: Infection in genitourinary cancer patients during cancer chemotherapy. Acta Urol. Jpn., 40, 221 (1994).

    Google Scholar 

  7. Maher, D. W., Lieschke, G. J., Green, M. et al.: Filgrastim in patients with chemotherapy-induced febrile neutropenia. A double-blind, placebo-controlled trial. Ann. Intern. Med., 121, 492 (1994).

    PubMed  Google Scholar 

  8. Schimpff, S. C.: Growth factors and empiric therapy with antibiotics: Should they be used concurrently? Ann. Intern. Med., 121, 538 (1994).

    PubMed  Google Scholar 

  9. Bodey, G. P., Anaissie, E. J., Gutterman, J. et al.: Role of granulocyte-macrophage colony-stimulating factors as adjuvant therapy for fungal infection in patients with cancer. Clin. Infect. Dis., 17, 705 (1993).

    PubMed  Google Scholar 

  10. Lee, J. W., Pizzo, P. A.: Management of the cancer patient with fever and prolonged neutropenia. Hematol. Oncol. Clin. N. Am., 7, 937 (1993).

    Google Scholar 

  11. Bodey, G. P.: Empirical antibiotic therapy for fever in neutropenic patients. Clin. Infect. Dis., 17(Suppl. 2), 378 (1993).

    Google Scholar 

  12. Klastersky, J.: Empirical therapy for bacterial infections in neutropenic patients. Supprt. Care Cancer, 2, 347 (1994).

    Google Scholar 

  13. Schimpf, S. C., Scott, D. A., Wade, J. C.: Infections in cancer patients; some controversial issue. Supprt Care Cancer, 2, 94 (1994).

    Google Scholar 

  14. Klastersky, J.: Prevention and therapy of fungal infections in cancer patients. A review of recent published information. Supprt Care Cancer, 3, 393 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matsumoto, T., Takahashi, K., Tanaka, M. et al. Infectious Complications of Combination Anticancer Chemotherapy for Urogenital Cancers. Int Urol Nephrol 31, 7–14 (1999). https://doi.org/10.1023/A:1007107403610

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1007107403610

Keywords

Navigation