Abstract
We reviewed the infectious complications in 207 courses of anticancer chemotherapy to 93 patients with urogenital cancer. Thirty episodes (14.5%) of neutropenic fever containing 9 cases (4.3%) of infection were observed. Five patients (16.7%) had pyelonephritis, one (3.3%) had acute prostatitis, two (6.6%) had pneumonia and one (3.3%) had bacteraemia. Multivariate analysis revealed that the infectious complications during anticancer chemotherapy were mainly associated with urinary diversion, hydronephrosis and duration of severe neutropenia (<500/mm3).
These results suggest that infectious complications should be prevented in patients with urinary diversion, hydronephrosis and severe neutropenia during anticancer chemotherapy for urogenital cancer.
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References
Pizzo, P. A.: Granulocytopenia and cancer therapy: Past problems, current solutions, future challenge. Cancer, 54, 2649 (1984).
Sculier, J. P., Wheets, D., Klastersky, J.: Causes of death in febrile granulocytopenic cancer patients receiving empiric antibiotic therapy. Eur. J. Cancer Clin. Oncol., 20, 55 (1984).
Naito, S., Kuroiwa, T., Ueda, T. et al.: Combination chemotherapy with intra-arterial cisplatin and doxorubicin plus intravenous methotrexate and vincristine for local advanced bladder cancer. J. Urol., 154, 1704 (1995).
Philoppt-Howard, J.: Infections in neutropenic patients. Curr. Opin. Infect. Dis., 8, 234 (1995).
Bodey, G. P., Buckley, M., Sathe, T. S. et al.: Quantitative relationship between circulating leukocytes and infection in patients with acute leukemia. Ann. Intern. Med., 64, 328 (1966).
Ito, Y., Komeda, H., Saitoh, A. et al.: Infection in genitourinary cancer patients during cancer chemotherapy. Acta Urol. Jpn., 40, 221 (1994).
Maher, D. W., Lieschke, G. J., Green, M. et al.: Filgrastim in patients with chemotherapy-induced febrile neutropenia. A double-blind, placebo-controlled trial. Ann. Intern. Med., 121, 492 (1994).
Schimpff, S. C.: Growth factors and empiric therapy with antibiotics: Should they be used concurrently? Ann. Intern. Med., 121, 538 (1994).
Bodey, G. P., Anaissie, E. J., Gutterman, J. et al.: Role of granulocyte-macrophage colony-stimulating factors as adjuvant therapy for fungal infection in patients with cancer. Clin. Infect. Dis., 17, 705 (1993).
Lee, J. W., Pizzo, P. A.: Management of the cancer patient with fever and prolonged neutropenia. Hematol. Oncol. Clin. N. Am., 7, 937 (1993).
Bodey, G. P.: Empirical antibiotic therapy for fever in neutropenic patients. Clin. Infect. Dis., 17(Suppl. 2), 378 (1993).
Klastersky, J.: Empirical therapy for bacterial infections in neutropenic patients. Supprt. Care Cancer, 2, 347 (1994).
Schimpf, S. C., Scott, D. A., Wade, J. C.: Infections in cancer patients; some controversial issue. Supprt Care Cancer, 2, 94 (1994).
Klastersky, J.: Prevention and therapy of fungal infections in cancer patients. A review of recent published information. Supprt Care Cancer, 3, 393 (1995).
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Matsumoto, T., Takahashi, K., Tanaka, M. et al. Infectious Complications of Combination Anticancer Chemotherapy for Urogenital Cancers. Int Urol Nephrol 31, 7–14 (1999). https://doi.org/10.1023/A:1007107403610
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DOI: https://doi.org/10.1023/A:1007107403610