Abstract
The authors report a case of pineocytoma in a 44-year-old woman suffering from headache, vomiting and Parinaud syndrome. At histopathological examination the neoplasm showed a ill-defined lobulate pattern with some small pineocytomatous rosettes. The electron-microscopy revealed cells of moderate size and oval nuclei with smooth nuclear envelopes; well-developed organelles were found in the, abundant cytoplasm. The chromosome analysis revealed this kariotype: 58–59, XXX, −4, −5, −13, −14, −15, +19. This is the first report of a pineocytoma with ultrastructural and cytogenetic study; it confirms the literature findings of the electron-microscopy, whereas there is partial accordance with the previous cytogenetic studies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Tsunoda S, Sakaki T, Tsujimoto M, Yabuno T, Tsuzuki T, Nakamura M, Hiramatsu K, Morimoto T, Boku E, Iwanaga H, Asada H: Clinicopathological study on pineocytoma. Brain Tumor Pathol 12: 31-37, 1995
Rainho CA, Rogatto SR, Correa de Moraes L, Barbieri-Neto J: Cytogenetic study of a pineocytoma. Cancer Genet Cytogenet 64: 127-132, 1992
Bello MJ, Rey JA, De Campos JM, Kusak ME: Chromosomal abnormalities in a pineocytoma. Cancer Genet Cytogenet 71: 185-186, 1993
Min KW, Scheithauer BW, Bauserman SC: Pineal parenchymal tumors: an ultrastructural study with prognostic implications. Ultrastruct Pathol 18: 69-85, 1994
Jouvet A, Fevre-Montange M, Besancon R, Derrington E, Saint-Pierre G, Belin MF, Pialat J, Lapras C: Structural and ultrastructural characteristics of human pineal gland and pineal parenchymal tumors. Acta Neuropathol 88: 334-348, 1994
Numoto RT: Pineal parenchymal tumors: cell differentiation and prognosis. J Cancer Res Clin Oncol 120: 683-690, 1994
Fevre-Montagne M, Jouvet A, Privat K, Korf HW, Champier J, Reboul A, Aguera M, Mottolese C: Immunohistochemical, ultrastructural, biochemical and in vitro studies of a pineocytoma. Acta Neuropathol 95: 532-539, 1998
Poulsgard L, Ronne M: Cytogenetic analysis of common nervous system tumors in adults. In: Molecular Genetics of Nervous System Tumors. Levine AJ, Schmidek HH (eds) Wiley-Liss, New York, 1993, p 225
Mitelman F: Catalog of chromosome aberrations in cancer. 5th edn., Johansson B, Mertens F (eds), Wiley-Liss, New York
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dario, A., Cerati, M., Taborelli, M. et al. Cytogenetic and Ultrastructural Study of a Pineocytoma Case Report. J Neurooncol 48, 131–134 (2000). https://doi.org/10.1023/A:1006400418607
Issue Date:
DOI: https://doi.org/10.1023/A:1006400418607