Abstract
Lecithin:cholesterol acyltransferase (LCAT) activity was evaluated in sera from cows with ketosis and in some with left displacement of the abomasum (LDA) that occurred during early lactation. The enzyme activities of 652±214 U (mean±SD) in cows with ketosis (n = 6) and 683±110 U in those with LDA (n = 5) were significantly (p<0.01) decreased compared to those in healthy normal cows (994±65 U, n = 8). Serum concentrations of free cholesterol, cholesteryl esters (CE) and phospholipids were similarly decreased in the two diseases. Cows whose LCAT activity and CE concentration were lower than the normal values were detected while in the non-lactating stage, and some of these cows had ketosis after parturition. It is suggested that evaluation of the LCAT activity and of the CE concentration during the non-lactating stage would be useful in detecting cows that are susceptible to postparturient disorders such as ketosis.
Similar content being viewed by others
REFERENCES
Baird, G.D., 1982. Primary ketosis in the high-producing dairy cow: clinical and subclinical disorders, treatment, prevention, and outbreak. Journal of Dairy Science, 65, 1–10
Baird, G.D., Hibbitt, K.G., Hunter, G.D., Lund, P., Stubbs, M. and Krebs, H.A., 1968. Biochemical aspects of bovine ketosis. Biochemical Journal, 107, 683–689
Brumby, P.E., Anderson, M., Tuckley, B. and Storry, J.E., 1975. Lipid metabolism in the cow during starvation-induced ketosis. Biochemical Journal, 146, 609–615
Gerloff, B.J., Herdt, T.H. and Emery, R.S., 1986. Relationship of hepatic lipidosis to health and performance in dairy cattle. Journal of the American Veterinary Medical Association, 188, 845–850
Glomset, J.A., 1968. The plasma lecithin:cholesterol acyltransferase reaction. Journal of Lipid Research, 9, 155–167
Grohn, Y., Lindberg, L.A., Bruss, M.L. and Farver, T.B., 1983. Fatty infiltration of liver in spontaneously ketotic dairy cows. Journal of Dairy Science, 66, 2320–2328
Herdt, T.H., 1988. Fatty liver in dairy cows. Veterinary Clinics of North America: Food Animal Practice, 4, 269–287
Herdt, T.H., Liesman, J.S., Gerloff, B.J. and Emery, R.S., 1983. Reduction of serum triacylglycerol-rich lipoprotein concentrations in cows with hepatic lipidosis. American Journal of Veterinary Research, 44, 293–296
Krebs, H.A., 1966. Bovine ketosis.Veterinary Record, 78, 187–192
Kronfeld, D.S., 1965. Plasma non-esterified fatty acid concentrations in the dairy cow: responses to nutritional and hormonal stimuli, and significance in ketosis.Veterinary Record, 77, 30–34
Littledike, E.T., Young, J.W. and Beitz, D.C., 1981. Common metabolic diseases of cattle: ketosis, milk fever, grass tetany, and downer cow complex. Journal of Dairy Science, 64, 1465–1482
Marcos, E., Mazur, A., Cardot, P. and Rayssiguier, Y., 1990. Serum apolipoproteins B and A-I and naturally occurring fatty liver in dairy cows. Lipids, 25, 575–577
Morrow, D.A., 1976. Fat cow syndrome. Journal of Dairy Science, 59, 1625–1629
Nakagawa, H., Oikawa, S., Oohashi, T. and Katoh, N., 1997. Decreased serum lecithin:cholesterol acyltransferase activity in spontaneous cases of fatty liver in cows. Veterinary Research Communications, 21, 1–8
Noble, R.C., O'Kelly, J.C. and Moore, J.H., 1972. Observations on the lecithin: cholesterol acyltransferase system in bovine plasma. Biochimica et Biophysica Acta, 270, 519–528
Oikawa, S. and Katoh, N., 1995. Enzyme-linked immunosorbent assay for apolipoprotein A-I in the serum of cattle. American Journal of Veterinary Research, 56, 409–414
Oikawa, S., Katoh, N., Kawawa, F. and Ono, Y., 1997. Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum. American Journal of Veterinary Research, 58, 121–125
Pinsent, P.J.N., Neal, P.A. and Ritchie, H.E., 1961. Displacement of the bovine abomasum: a review of 80 clinical cases.Veterinary Record, 73, 729–735
Rayssiguier, Y., Mazur, A., Gueux, E., Reid, I.M. and Roberts, C.J., 1988. Plasma lipoproteins and fatty liver in dairy cows. Research in Veterinary Science, 45, 389–393
Reid, I.M., 1980. Incidence and severity of fatty liver in dairy cows.Veterinary Record, 107, 281–284
Uchida, E., Katoh, N. and Takahashi, K., 1992. Induction of fatty liver in cows by ethionine administration and concomitant decreases of serum apolipoproteins B-100 and A-I concentrations. American Journal of Veterinary Research, 53, 2035–2042
Uchida, E., Katoh, N. and Takahashi, K., 1995. The activity of lecithin:cholesterol acyltransferase in the serum of cows at parturition or with fatty liver.Veterinary Research Communications, 19, 343–351
Veenhuizen, J.J., Drackley, J.K., Richard, M.J., Sanderson, T.P., Miller, L.D. and Young, J.W., 1991. Metabolic changes in blood and liver during development and early treatment of experimental fatty liver and ketosis in cows. Journal of Dairy Science, 74, 4238–4253
Yamamoto, O., Oikawa, S. and Katoh, N., 1995. Enzyme-linked immunosorbent assay for serum apolipoprotein B-100, a major triglyceride-transport protein in dairy cows. American Journal of Veterinary Research, 56, 1413–1417
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakagawa, H., Katoh, N. Reduced Activity of Lecithin:Cholesterol Acyltransferase in the Serum of Cows with Ketosis and Left Displacement of the Abomasum. Vet Res Commun 22, 517–524 (1998). https://doi.org/10.1023/A:1006189603071
Issue Date:
DOI: https://doi.org/10.1023/A:1006189603071