Abstract
Detection and diagnosis of human malignant melanoma byPositron Emission Tomography (PET) using 18F-10B-L-BPA, a specificmelanogenesis-seeking compound synthesized for use in Boron NeutronCapture Therapy for malignant melanoma (NCT), has beendeveloped. This resulted in a novel, highly effectivemethodology for the selective three dimensional imaging ofmetastatic malignant melanomas, and for accurate determination of10B concentration in the tumor and surrounding tissue,providing almost all diagnostic information necessary for completenon-invasive radiation dose planning in the treatment ofmalignant melanoma both for NCT as well asother therapeutic modalities.
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Mishima, Y., Imahori, Y., Honda, C. et al. In vivo diagnosis of human malignant melanoma with positron emission tomography using specific melanoma-seeking 18F-DOPA analogue. J Neurooncol 33, 163–169 (1997). https://doi.org/10.1023/A:1005746020350
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DOI: https://doi.org/10.1023/A:1005746020350