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Lipase-catalyzed synthesis of vitamin C fatty acid esters

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Abstract

Fatty acid esters of vitamin C (ascorbic acid) where synthesized in a mainly solid-phase system in the presence of small amounts of organic solvent (acetone or t-butanol) catalyzed by immobilized lipase B from Candida antarctica.Highest reaction rates and yields of isolated products were obtained using fatty acid vinyl esters, e.g., 6-O-palmitoyl-l-ascorbic acid was obtained in 91% isolated yield after 48 h. As vitamin C and its esters are very sensitive to oxidation, a mild extraction method for the isolation of reaction products was developed.

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Authors and Affiliations

  1. Institute of Technical Biochemistry, University of Stuttgart, Allmandring 31, D-70569, Stuttgart, Germany

    Youchun Yan, Uwe T. Bornscheuer & Rolf D. Schmid

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  1. Youchun Yan
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  2. Uwe T. Bornscheuer
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  3. Rolf D. Schmid
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Correspondence to Rolf D. Schmid.

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Yan, Y., Bornscheuer, U.T. & Schmid, R.D. Lipase-catalyzed synthesis of vitamin C fatty acid esters. Biotechnology Letters 21, 1051–1054 (1999). https://doi.org/10.1023/A:1005620125533

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  • DOI: https://doi.org/10.1023/A:1005620125533

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