Abstract
Treatment of psychosocial/emotional distress as a strategy for diminishing chest pain in such patients remains entirely unutilized in standard care. Sixty-three patients with known or suspected CAD were entered in an aggressive lifestyle modification program. Patients completed the Symptom Checklist 90—Revised (SCL90R) at the diagnostic interview session, at 3 and at 12 months. Statistically significant drops were observed on multiple scales of the SCL90R at both 3 and 12 months. An item from the SCL90R was used as a proxy for angina. Multiple measures of emotional distress at baseline were found to correlate with chest pain at baseline, but not a number of traditional cardiovascular risk factors. The chest pain item displayed improvement at both 3 and 12 months. Improvement on all scales of the SCL90R correlated with improvement in chest pain. It may be possible to control chest pain in some CAD patients with psychosocial interventions.
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REFERENCES
Allison, T. G., Williams, D. E., Miller, T. D., Patten, C. A., Bailey, K. R., Squires, R. W., and Gau, G. T. (1995). Medical and economic costs of psychologic distress in patients with coronary artery disease. Mayo Clin. Proc. 70: 734–742.
Amorosa-Tupler, B., Tapp, J. T., and Cardia, R.V. (1989). Stress management through relaxation and imagery in the treatment of angina pectoris. J. Cardiopulm. Rehab. 9: 348–355.
Andrews, T. C., Raby, K., Barry, J., Naimi, C. L., Allred, E., Ganz, P., and Selwyn, A. P. (1997). Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease. Circulation 95: 324–328.
Beitman, B. D., Mukerji, V., Russell, J. L., and Grafting, M. (1993). Panic disorder in cardiology patients: A review of the missouri panic/cardiology project. J. Psychosom. Med. 27(Suppl. I): 35–46.
Bengston, A., Herlitz, J., Karlsson, T., and Hjalmarson, A. (1996). Distress correlates with the degree of chest pain: A description of patients awaiting revascularization. Heart 75: 257–260.
Black, J. L., Allison, T. G., Williams, D. E., Rummans, T. A., and Gau G. T. (1998). Effect of intervention for psychological distress on rehospitalization rates in cardiac rehabilitation patients. Psychosomatics 39: 134–143.
Blumenthal, J. A., Jiang, W., Babyak, M. A., Krantz, D. S., Frid, D. J., Coleman, R. E., Waugh, R., Hanson, M., Appelbaum, M., O'Connor, C., and Morris, J. J. (1997). Stress management and exercise training in cardiac patients with myocardial ischemia. Arch. Intern. Med. 157: 2213–2223.
Blumenthal, J. A., Jiang, W., Waugh, R. A., Frid, D. J., Morris, J. J., Coleman, R. E., Hanson, M., Babyak, M., Thyrum, E. T., Krantz, D. S., and O'Connor, C. (1995). Mental stressinduced ischemia in the laboratory and ambulatory ischemia during daily life: Association and hemodynamic features. Circulation 92: 2102–2108.
Boltwood, M.D., Taylor, C. B., Burke, M. B., Grogin, H., and Giacomini, J. (1993). Anger report predicts coronary artery vasomotor response to mental stress in atherosclerotic segments. Am. J. Cardiol. 72: 1361–1365.
Bundy, C., Carroll, D., Wallace, L., and Nagle, R. (1994). Psychological treatment of chronic stable angina pectoris. Psychol. Health 10: 69–77.
Burg, M. M., Jain, D., Soufer, R., Kerns, R. D., and Zaret, B. L. (1993). Role of behavioral and psychological factors in mental stress induced silent left ventricular dysfunction in coronary artery disease. J. Am. Coll. Cardiol. 22(2): 440–448.
Cannon, R. O., Quyyumi, A. A., Mingemoyer, R., Stine, A. M., Gracely, R. H., Smith, W. B., Geraci, M. F., Black, B. C., Uhde, T. W., Wacliwiw, M. A., Maher, K., and Benjamin, S. B. (1994). Imipramine in patients with chest pain despite normal coronary angiograms. N. Engl. J. Med. 330: 1411–1417.
Chiles, J. A., Lambert, M. J., and Hatch, A. L. (1999). The impact of psychological interventions on medical cost offset: A meta-analytic review. Clin. Psychol. Sci. Pract. 6: 204–220.
Clarke, D. M., Smith, G. C., and Herrman, H. E. (1993). A comparative study of screening instruments for mental disorders in general hospital patients. Int. J. Psychiatry Med. 23(4): 323–337.
Collins, R., Ornish, D., Scherwitz, L., Schoenfield, D., Scheer, J., Elliot, M., Merrit, T., Horowitz, S., Wickmeyer, W., and Stangle, S. (1996). Are comprehensive lifestyle changes feasible and clinically beneficial? Preliminary results from the multicenter lifestyle heart trial. Psychosom. Med. 58: 85.
Davies, R. F., Goldberg, A. D., Forman, S., Pepine, C. J., Knatterud, G. L., Geller, N., Sopko, G., Pratt, C., Deanfield, J., Conti, C. R., and the ACIP Investigators (1997). Asymptomatic cardiac ischemia pilot (acip) study two year follow-up: Outcomes of patients randomized to initial strategies of medical therapy versus revascularization. Circulation 95: 2037–2043.
Deanfield, J. E., Shea, M., Kensett, M., Horlock, P., Wilson, R. A., deLansheere, C. M., and Selwyn, A. P. (1984). Silent myocardial ischemia due to mental stress. Lancet 2(8410): 1001–1005.
Derogatis, L. R. (1977). The Symptom Checklist 90-Revised, NCS Assessments, Minneapolis, MN.
Dusseldorp, E., van Elderen, T., Maes, S., Meulman, J., and Kraaij, V. (1999). A meta-analysis of psychoeducational programs for coronary heart disease patients. Health Psychol. 18(5): 506–519.
Finn, S. E. (1982). Base rates, utilities and DSMII: Shortcomings of fixed-rule systems of psychodiagnosis. J. Abnorm. Psychol. 91(4): 294–302.
Frasure-Smith, N., and Lesperance, F. (1998). Depression and anxiety increase physician costs during the first post-MI year. Psychosom. Med. 60: 99.
Friedman, M., Breall, W. S., Goodwin, M. L., Sparagon, B. J., Ghandour, G., and Fleischman, N. (1996). Effect of type a behavioral counseling on frequency of episodes of silent myocardial ischemia in coronary patients. Am. Heart J. 132: 933–937.
Gallacher, J. E. J., Hopkinson, C. A., Bennett, P., Burr, M. L., and Elwood, P. C. (1997). Effect of stress management on angina. Psychol. Health 12: 523–532.
Giubbini, R., Galli, M., Campini, R., Bosimini, E., Bencivelli, W., and Tavazzi, L. (1991). Effects of mental stress on myocardial perfusion in patients with ischemic heart disease. Circulation 83(Suppl. II): 100–107.
Goldberg, A.D., Becker, L.C., Bonsall, R., Cohen, J.D., Ketterer, M.W., Kaufman, P.G., Krantz, D. S., Light, K. C., McMahon, R. P., Noreuil, T., Pepine, C. J., Raczynski, J., Stone, P. H., Strother, D., Taylor, H., and Sheps, D. S., for the PIMI Investigators (1996). Ischemic, hemodynamic and neurohormonal responses to mental and exercise stress: Experience from the psychophysiological investigations of myocardial ischemia study (PIMI). Circulation 94: 2402–2409.
Hartman, C. H. (1979). Response of anginal pain to handwarming. Biofeed. Self-Regul. 4: 355–357.
Herrman, C. (1997). International experiences with the hospital anxiety and depression scale—A review of validation data and clinical results. J. Psychosom. Res. 42(1): 17–41.
Ironson, G., Taylor, C. B., and Boltwood, M. (1992). Effects of anger on left ventricular ejection fraction in coronary artery disease. Am. J. Cardiol. 70(3): 281–285.
Johnson, D.W., and Lo, C. R. (1983). The effects of cardiovascular feedback and relaxation on angina pectoris. Behav. Psychother. 11: 257–264.
Kessler, R. C., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Eshelman, S., Wittchen, H. U., and Kendler, K. S. (1994). Lifetime and 12-month prevalence of DSMIIIR psychiatric disorders in the united states: Results from the national comorbidity survey. Arch. Gen. Psychiatry 51(1): 8–19.
Ketterer, M.W. (1993). Secondary prevention of ischemic heart disease: The case for aggressive behavioral monitoring and intervention. Psychosomatics 34(6): 478–484.
Ketterer, M.W., Kenyon, L., and Gheorgiade, M. (1994). Arandomly-assigned, controlled pilot study of triaging and psychiatric consultation in acute myocardial infarction. Psychosom. Med. 56: 173.
Ketterer, M.W., Huffman, J., Lumley, M. A., Wassef, S., Gray, L., Kenyon, L., Kraft, P., Brymer, J., Rhoads, K., Lovallo, W. R., and Goldberg, A. D. (1997). Five year followup for adverse outcomes in males with at least minimally positive angiograms: The importance of “denial” in assessing psychosocial risk factors. J. Psychosom. Res. 44(2): 241–250.
Ketterer, M. W., Freedland, K. E., Krantz, D. S., Kaufmann, P., Forman, S., Greene, A., Raczysnki, J., Knatterud, G., Light, K., Carney, R. M., Stone, P., Becker, L., and Sheps, D. S., for the PIMI Investigators (2000a). Psychological correlates of mental stress induced ischemia in the laboratory: The psychophysiological investigations of myocardial ischemia (PIMI) study. J. Health Psychol. 5(1): 75–85.
Ketterer, M.W., Mahr, G., and Goldberg, A.D. (2000b). Psychological factors affecting a medical condition: Ischemic coronnary heart disease. J. Psychosom. Res. 48: 357–367.
Klimes, I., Mayou, R. A., Rearce, M. J., Cole, L., and Fagg, J. R. (1990). Psychological treatment for atypical noncardiac chest pain: A controlled evaluation. Psychol. Med. 20: 605–611.
Krantz, D. S., Hedges, S. M., Gabbay F. H., Klein, J., Gottdiener, J. S., and Rozanski, A. (1994). Triggers of angina and st-segment depression in ambulatory patients with coronary artery disease: Evidence for an uncoupling of angina and ischemia. Am. Heart J. 128(4): 703–712.
Ladwig, K. H., Roll, G., Breithardt, G., and Borggrefe, M. (1999). Extracardiac contributions to chest pain perception in patients 6 months after acute myocardial infarction. Am. Heart J. 137: 528–534.
Lewin, B. (1997). The psychological and behavioral management of angina. J. Psychosom. Res. 43(5): 453–462.
Light, K. C., Herbst, M. C., Bragdon, E. E., Hinderliter, A. L., Koch, G. G., Davis, M. R., and Sheps, D. S. (1991). Depression and type a behavior pattern in patients with coronary artery disease: Relationships to painful versus silent myocardial ischemia and B-endorphin responses during exercise. Psychosom. Med. 53: 669–683.
Milani, R.V., Lavie, C. J., and Cassidy, M.M. (1996). Effects of cardiac rehabilitation and exercise training programs on depression in patients after major coronary events. Am. Heart J. 132: 726–732.
Mumford, E., Schlesinger, H. J., and Glass, G.V. (1982). The effect of psychological intervention on recovery from surgery and heart attacks: An analysis of the literature. Am. J. Public Health 72(2): 141–151.
Ornish, D., Brown, S. E., and Scherwitz, L. W. (1990). Can lifestyle changes reverse coronary heart disease? Lancet 336: 129–133.
Payne, T. J., Johnson, C. A., Penzien, D. B., Porzelius, J., Eldridge, G., Parisi, S., Backham, J., Pbert, L., Prather, R., and Rodriguez, G. (1994). Chest pain self-management training for patients with coronary artery disease. J. Psychosom. Res. 38(5): 409–418.
Rapp, M. S., and Thomas, M. R. (1975). Alleviation of angina pectoris following systematic desensitization. Can. Psychiatry J. 20: 96.
Rozanski, A., Bairey, C.N., Krantz, D. S., Friedman, J., Resser, K. J., Morell, M., Hilton-Chalfen, S., Hestrin, L., Bietendorf, J., and Berman, D. S. (1988). Mental stress and the induction of silent myocardial ischemia in patients with coronary artery disease. N. Engl. J. Med. 318: 1005–1012.
Schoebel, F. C., Frazier, H., Jessurun, G. A. J., De Jongste, M. J. L., Kadipasaoglu, K. A., Jax, T.W., Heintzen, M. P., Cooley, D. A., and Strauer, B. E. (1997). Refractory angina pectoris in end-stage coronary artery disease: Evolving therapeutic concepts. Am. Heart J. 134: 587–602.
Stetson, B. A., Rahn, J. M., Dubbert, P. M., Wilner, B. I., and Mecury, M. G. (1997). Prospective evaluation of the effects of stress on exercise adherence in community-residing women. Health Psychol. 16(6): 515–520.
Sullivan, M. D., LaCroix, A. Z., Baum, C., Grothaus, L. C., and Katon, W. J. (1997). Functional status in coronary artery disease: A one-year prospective study of the role of anxiety and depression. Am. J. Med. 103: 348–356.
Swinson, R. P., Soulios, C., Cox, B. J., and Kuch, K. (1992). Brief treatment of emergency room patients with panic attacks. Am. J. Psychiatry 149(7): 944–946.
Thompson, D., Hylan, T. R., McMullen, W., Romeis, M. E., Buesching, D., and Oster, G. (1998). Predictors of medical offset effect among patients receiving antidepressant therapy. Am. J. Psychiatry 155: 824–827.
Tu, J. V., Pashos, C. L., Naylor, C. D., Chen, E., Normand, S. L., Newhouse, J. P., and McNeil, B. J. (1997). Use of cardiac procedures and outcomes in elderly patients with myocardial infarction in the united states and canada. N. Engl. J. Med. 336: 1500–1505.
Van Boven, A. J., Jukema, J. W., Zwinderman, A. H., Crijns, H. J. G. M., Lie, K. I., and Bruschke, A.V.G., on behalf of the REGRESS Study Group (1996). Reduction of transient myocardial ischemia with prevastatin in addition to the conventional treatment in patients with angina pectoris. Circulation 94: 1503–1505.
Verthein, U., and Kohler, T. (1997). The correlation between everyday stress and angina pectoris: A longitudinal study. J. Psychosom. Res. 43(3): 241–245.
Yusuf, S., Wittes, J., and Friedman, L. (1988). Overview of results of randomized clinical trials in heart disease, part II. JAMA 260: 2259–2263.
Zigmund, A. S., and Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatr. Scand. 67: 361–370.
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Ketterer, M.W., Fitzgerald, F., Keteyian, S. et al. Chest Pain and the Treatment of Psychosocial/Emotional Distress in CAD Patients. J Behav Med 23, 437–450 (2000). https://doi.org/10.1023/A:1005521014919
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DOI: https://doi.org/10.1023/A:1005521014919