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Voltage-sensitive dyes for monitoring multineuronal activity in the intact central nervous system

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Abstract

Optical monitoring of activity provides new kinds of information about brain function. Two examples are discussed in this article. First, the spike activity of many individual neurons in small ganglia can be determined. Second, the spatio-temporal characteristics of coherent activity in the brain can be directly measured. This article discusses both general characteristics of optical measurements (sources of noise) as well as more methodological aspects related to voltage-sensitive dye measurements from the nervous system. 1998 © Chapman & Hall

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Authors and Affiliations

  1. Georgetown Institute of Cognitive and Computational Sciences, Georgetown University Washington, USA

    Jian-Young Wu

  2. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, USA

    Ying-Wan Lam, Chun X. Falk, Lawrence B. Cohen & Jing Fang

  3. Department of Physiology, University of Connecticut Health Center Farmington, USA

    Leslie Loew

  4. Department of Physics, University of California, La Jolla, USA

    James C. Prechtl & David Kleinfeld

  5. Georgetown Institute of Cognitive and Computational Sciences, Georgetown University, Washington, USA

    Yang Tsau

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  1. Jian-Young Wu
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Wu, JY., Lam, YW., Falk, C.X. et al. Voltage-sensitive dyes for monitoring multineuronal activity in the intact central nervous system. Histochem J 30, 169–187 (1998). https://doi.org/10.1023/A:1003295319615

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