Abstract
L-galactonic acid γ -lactone appear to influence ascorbic acid production in strains of Saccharomyces cerevisiae, Clavispora lusitaniae, Cryptococcus terreus, Pichia fermentans in which this is undetected whenever glucose represents the sole carbon source. Cryptococcus terreus (strains DBVP 6012 and 6242) does not show ascorbic acid production either in presence or in the absence of L-galactonic acid γ -lactone. This feature is probably connected to the insensibility of the strain to the lycorine, an alkaloid which commonly inhibits cell division probably by blocking L-galactonic acid γ -lactone convertion into ascorbate.
Similar content being viewed by others
References
Arrigoni O (1994) Ascorbate system in plant development. J. Bioenerg. Biomem. 26: 407–419
Arrigoni O, Arrigoni Liso R & Calabrese G (1975) Lycorine as an inhibitor of ascorbic acid biosynthesis. Nature 256: 513–514
Bleeg HS (1966) L-Ascorbic acid in yeast and isolation of L-galactono-γ-lactone oxidase from the mitochondria. Enzymologia 31: 105–112
Bleeg HS & Christensen F (1982) Biosynthesis of ascorbate in yeast. Purification of L-galactono-1,4-lactone oxidase with properties different from mammalian L-gulonolactone oxidase. Eur. J. Biochem. 127: 391–396
Chayen J (1953) Ascorbic acid and its intracellular localization, with special reference to plants. In: Bourne GH & Danielli JF (Eds) International Review of Cytology, Vol. 2 (pp 78–113) Academic Press, New York
De Gara L, Paciolla C, Tommasi F & Arrigoni O (1994) ‘In vivo’ inhibition of galactono-γ-lactone convertion to ascorbate by lycorine. J. Plant Physiol. 144: 649–653
De Leo P, Dalessandro G, De Santis A & Arrigoni O (1973) Inhibitory effect of lycorine on cell division and cell elongation. Pl. Cell Physiol. 14: 481–486
Garuccio I & Arrigoni O (1989) Differente sensibilità dei lieviti alla licorina. Boll. Soc. Ital. Biol. Sperim. 65: 501–508
Garuccio I, Onofri S, Evidente A & Arrigoni O (1989a) Stimolazione della crescita del Cryptococcus terreus indotta dalla licorina. Giorn. Bot. Ital. 123: 180
—(1989b) Further investigations on lycorine effects on yeast growth. Giorn. Bot. Ital. 123: 132
Heick HMC, Graff GLA & Humpers JEC (1972) The occurrence of ascorbic acid among the yeasts. Can. J. Microbiol. 18: 597–600
Heick HMC, Stewart HB, Graff GLA & Humpers JEC (1969) Occurrence of ascorbic acid in the yeast Lipomyces starkeyi. Can. J. Biochem. 47: 752–753
Liso R, Calabrese G, Bitonti MB & Arrigoni O (1984) Relationship between ascorbic acid and cell division. Exp. Cell Res. 150: 314–320
Loewus FA (1980) L-Ascorbic acid: metabolism, biosynthesis, function. In: Stumpf PK & Conn EE (Eds) The Biochemistry of Plants, Vol. 3 (pp 77–99) Academic Press, New York
Nishikimi M, Noguchi E & Yagi K (1978) Occurrence in yeast of L-galactonolactone oxidase which is similar to a key enzyme for ascorbic acid biosynthesis in animals. Arch. Biochem. Biophys. 191: 479–486
—(1980) Redox properties of L-galactonolactone oxidase purified from baker's yeast. Biochem. Int. 1: 155–161
Sivarama Sastry K & Sarma SP (1957) Glucuronic acid, a precursor of ascorbic acid in Aspergillus niger. Nature 179: 44–45
Takahashi T, Mitsumoto M & Kayamori H (1960) Production of D-araboascorbic acid by Penicillium. Nature 188: 411–412
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Onofri, S., Poerio, E., Serangeli, P. et al. Influence of L-galactonic acid γ -lactone on ascorbate production in some yeasts. Antonie Van Leeuwenhoek 71, 277–280 (1997). https://doi.org/10.1023/A:1000161921389
Issue Date:
DOI: https://doi.org/10.1023/A:1000161921389