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Fusogenic Viral Protein-Based Near-Infrared Active Nanocarriers for Biomedical Imaging

Cite this: ACS Biomater. Sci. Eng. 2021, 7, 7, 3351–3360
Publication Date (Web):June 10, 2021
https://doi.org/10.1021/acsbiomaterials.1c00267
Copyright © 2021 American Chemical Society
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    Abstract

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    An effective drug delivery system (DDS) relies on an efficient cellular uptake and faster intracellular delivery of theranostic agents, bypassing the endosomal mediated degradation of the payload. The use of viral nanoparticles (VNPs) permits such advancement, as the viruses are naturally evolved to infiltrate the host cells to deliver their genetic material. As a proof of concept, we bioengineered the vesicular stomatitis virus glycoprotein (VSV-G)-based near-infrared (NIR) active viral nanoconstructs (NAVNs) encapsulating indocyanine green dye (ICG) for NIR bioimaging. NAVNs are spherical in size and have the intrinsic cellular-fusogenic properties of VSV-G. Further, the NIR imaging displaying higher fluorescence intensity in NAVNs treated cells suggests enhanced cellular uptake and delivery of ICG by NAVNs compared to the free form of ICG. The overall study highlights the effectiveness of VSV-G-based VNPs as an efficient delivery system for NIR fluorescence imaging.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsbiomaterials.1c00267.

    • SDS-PAGE determining the purity of VNPs collected from the conditioned media of VSV-G transected cells (Figure S1) and the calibration curve of indocyanine green (ICG) dye (Figure S2) (PDF)

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    Cited By

    This article is cited by 2 publications.

    1. Sheeba Rehman, Suman Bishnoi, Rajarshi Roy, Anshu Kumari, Harikrishnan Jayakumar, Sharad Gupta, Parimal Kar, Asit K. Pattnaik, Debasis Nayak. Emerging Biomedical Applications of the Vesicular Stomatitis Virus Glycoprotein. ACS Omega 2022, 7 (37) , 32840-32848. https://doi.org/10.1021/acsomega.2c03517
    2. Kyeong Rok Kim, Ae Sol Lee, Su Min Kim, Hye Ryoung Heo, Chang Sup Kim. Virus-like nanoparticles as a theranostic platform for cancer. Frontiers in Bioengineering and Biotechnology 2023, 10 https://doi.org/10.3389/fbioe.2022.1106767
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