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Plasma gelsolin as a biomarker of acute rheumatic carditis

Published online by Cambridge University Press:  18 November 2014

Mustafa Argun ,
Ali Baykan ,
Figen Narin ,
Abdullah Özyurt ,
Özge Pamukçu ,
Ferhan Elmalı ,
Kazım Üzüm  and
Nazmi Narin
Mustafa Argun*
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Ali Baykan
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Figen Narin
Affiliation:
Department of Medical Biochemistry, Erciyes University Medical Faculty, Kayseri, Turkey
Abdullah Özyurt
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Özge Pamukçu
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Ferhan Elmalı
Affiliation:
Department of Biostatistics and Medical Informatics, Erciyes University Medical Faculty, Kayseri, Turkey
Kazım Üzüm
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Nazmi Narin
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
*
Correspondence to: M. Argun, MD, Department of Pediatrics, Erciyes University Medical Faculty, 38039 Kayseri, Turkey. Tel: +90 352 207 6666; Fax: +90 352 437 5825; E-mail: dr.margun@hotmail
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Abstract

Background

Acute rheumatic fever is an autoimmune, inflammatory, and multi-systemic disease secondary to pharyngitis and is caused by group A streptococcus. In developing countries, acute rheumatic fever is the most common cause of acquired heart disease. Gelsolin is a calcium-dependent, multi-functional actin-regulatory protein circulating in the plasma of healthy human beings. The correlation between blood gelsolin levels and inflammatory conditions suggests the potential benefit of gelsolin as a prognostic marker. The aim of the present study was to appraise the association of gelsolin and acute rheumatic carditis in childhood.

Materials and Methods

Plasma gelsolin levels were measured and echocardiographic examinations were performed in patients (n=37) with acute rheumatic carditis and compared with those of age- and gender-matched healthy controls (n=24).

Results

The plasma gelsolin levels in children with acute rheumatic carditis were significantly lower compared with controls (197±218 versus 322±255 mg/L, p=0.039). There was a significant correlation among gelsolin levels and the grade of mitral regurgitation (p=0.030), left ventricular end-diastolic diameter (p=0.017), and left ventricular end-systolic diameter (p=0.028) at diagnosis.

Conclusions

Levels of the gelsolin plasma isoform were decreased in patients with acute rheumatic carditis compared with healthy controls. Gelsolin may be used as a biochemical marker for acute rheumatic carditis.

Keywords

Acute rheumatic carditisgelsolinbiomarkerchildren
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 7 , October 2015 , pp. 1276 - 1280
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Copyright
© Cambridge University Press 2014 

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