Pituitary tumor-transforming gene and its binding factor in endocrine cancer

Vicki E. Smith; Jayne A. Franklyn; Christopher J. McCabe

doi:10.1017/S1462399410001699

Pituitary tumor-transforming gene and its binding factor in endocrine cancer

Published online by Cambridge University Press: 03 December 2010

Vicki E. Smith ,

Jayne A. Franklyn and

Christopher J. McCabe

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Vicki E. Smith: Affiliation:
School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, UK.
Jayne A. Franklyn: Affiliation:
School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, UK.
Christopher J. McCabe*: Affiliation:
School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, UK.
*: *Corresponding author: Christopher J. McCabe, School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK. Email: mccabcjz@bham.ac.uk

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Abstract

The pituitary tumor-transforming gene (PTTG1) encodes a multifunctional protein (PTTG) that is overexpressed in numerous tumours, including pituitary, thyroid, breast and ovarian carcinomas. PTTG induces cellular transformation in vitro and tumourigenesis in vivo, and several mechanisms by which PTTG contributes to tumourigenesis have been investigated. Also known as the human securin, PTTG is involved in cell cycle regulation, controlling the segregation of sister chromatids during mitosis. This review outlines current information regarding PTTG structure, expression, regulation and function in the pathogenesis of neoplasia. Recent progress concerning the use of PTTG as a prognostic marker or therapeutic target will be considered. In addition, the PTTG binding factor (PBF), identified through its interaction with PTTG, has also been established as a proto-oncogene that is upregulated in several cancers. Current knowledge regarding PBF is outlined and its role both independently and alongside PTTG in endocrine and related cancers is discussed.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 12 , January 2010 , e38

DOI: https://doi.org/10.1017/S1462399410001699 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2010

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Pituitary tumor-transforming gene and its binding factor in endocrine cancer

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Pituitary tumor-transforming gene and its binding factor in endocrine cancer

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