Hostname: page-component-76fb5796d-45l2p Total loading time: 0 Render date: 2024-04-26T10:32:59.571Z Has data issue: false hasContentIssue false
  • English
  • Français

Can Risk-Taking Be an Endophenotype for Bipolar Disorder? A Study on Patients with Bipolar Disorder Type I and Their First-Degree Relatives

Published online by Cambridge University Press:  14 February 2013

Ceren Hıdıroğlu ,
Özlem Demirci Esen ,
Zeliha Tunca ,
Şehnaz Neslihan Gűrz Yalçìn ,
Lauren Lombardo ,
David C. Glahn  and
Ayşegül Özerdem
Ceren Hıdıroğlu*
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey
Özlem Demirci Esen
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey
Zeliha Tunca
Affiliation:
Department of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
Şehnaz Neslihan Gűrz Yalçìn
Affiliation:
Department of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey
Lauren Lombardo
Affiliation:
Department of Psychology, Temple University, Philadelphia, Pennsylvania
David C. Glahn
Affiliation:
Department of Psychiatry, Yale University, New Haven, Connecticut Olin Neuropsychiatric Research Center, Institute of Living Whitehall Research Building, Hartford, Connecticut
Ayşegül Özerdem
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey Department of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey Brain Dynamics and Research Center, Dokuz Eylul University, Izmir, Turkey
*
Correspondence and reprint requests to: Ceren Hıdıroğlu, Dokuz Eylul University, Health Sciences Institute, Department of Neuroscience, Izmir, Turkey. E-mail: cerennh@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Risk-taking behavior and impulsivity are core features of bipolar disorder. Whether they are part of the inherited aspect of the illness is not clear. We aimed to evaluate risk-taking behavior as a potential endophenotype for bipolar disorders, and its relationship with impulsivity and illness features. The Balloon Analogue Risk Task (BART) and Barratt Impulsiveness Scale-11 (BIS-11) were used to assess risk-taking behavior and impulsivity respectively in 30 euthymic bipolar I patients (BD), their 25 asymptomatic first-degree relatives (BD-R), and 30 healthy controls (HC). The primary BART outcome measure was the behavioral adjustment score (number of pumps after trials where the balloon did not pop minus the number of pumps after trials where the balloon popped). BD (p < .001) and BD-R (p = .001) had similar and significantly lower adjustment scores than HC. Only BD scored significantly higher on BIS-11 total (p = .01) and motor (p = .04) subscales than HC. Neither the BART, nor impulsivity scores associated with illness features. A limitation of this study is medicated patients and a heterogeneous BD-R were included. Riskiness may be a candidate endophenotype for bipolar disorder as it appears independently from illness features, presents similarly in BD and BD-R groups and differs from impulsivity. (JINS, 2013, 19, 1–9)

Keywords

Bipolar disorderRisk-takingImpulsive behaviorEndophenotypeFirst-degree relativeThe Balloon Analogue Risk Task
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 4 , April 2013 , pp. 474 - 482
Copyright
Copyright © The International Neuropsychological Society 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders. DSM-IV-TR. (Revised 4th ed.). Washington, DC: American Psychiatric Association Press.Google Scholar
Anokhin, A.P., Golosheykin, S., Grant, J., Heath, A.C. (2009). Heritability of risk-taking in adolescence: A longitudinal twin study. Twin Research and Human Genetics, 12(4), 366–371.CrossRefGoogle ScholarPubMed
Aydemir, O., Deveci, A. 2003. Validity and reliability of structured interview for Hamilton Depression Rating Scale Seasonal Affective Disorders Version. VIIth Annual Spring Symposium of Psychiatric Association of Turkey Abstract Book, p. 187.Google Scholar
Bora, E., Vahip, S., Akdeniz, F. (2006). Sustained attention deficits in manic and euthymic patients with bipolar disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30(6), 1097–1102.CrossRefGoogle ScholarPubMed
Chamberlain, S.R., Sahakian, B.J. (2007). The neuropsychiatry of impulsivity. Current Opinion in Psychiatry, 20, 255–261.CrossRefGoogle ScholarPubMed
Cheng, G.L.F., Tang, J.C.Y., Li, F.W.S., Lau, E.Y.Y., Lee, T.M.C. (2012). Schizophrenia and risk-taking: Impaired reward but preserved punishment processing. Schizophrenia Research, 136, 122–127.CrossRefGoogle ScholarPubMed
Christodoulou, T., Lewis, M., Ploubidis, G.B., Frangou, S. (2006). The relationship of impulsivity to response inhibition and decision-making in remitted patients with bipolar disorder. European Psychiatry, 21, 270–273.CrossRefGoogle ScholarPubMed
Cohen, J. (1977). Statistical power analysis for behavioral sciences (Revised ed.). New York: Academic Press.Google Scholar
Congdon, E., Canli, T. (2008). A neurogenetic approach to impulsivity. Journal of Personality, 76(6), 1447–1484.CrossRefGoogle ScholarPubMed
Cyders, M.A., Coskunpinar, A. (2011). Measurement of constructs using self-report and behavioral lab tasks: Is there overlap in nomothetic span and construct representation for impulsivity? Clinical Psychology Review, 31(6), 965–982.CrossRefGoogle ScholarPubMed
Evenden, J. (1999). Impulsivity: A discussion of clinical and experimental findings. Journal of Psychopharmacology, 13(2), 180–192.CrossRefGoogle ScholarPubMed
First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B.W. (1996). Structured clinical interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). Washington, DC: American Psychiatric Press.Google Scholar
Fleck, D.E., Shear, P.K., Strakowski, S.M. (2005). Processing efficiency and sustained attention in bipolar disorder. Journal of the International Neuropsychological Society, 11(1), 49–57.CrossRefGoogle ScholarPubMed
Floden, D., Alexander, M.P., Kubu, C.S., Katz, D., Stuss, D.T. (2008). Impulsivity and risk-taking behavior in focal frontal lobe lesions. Neuropsychologia, 46, 213–223.CrossRefGoogle ScholarPubMed
Frantom, L.V., Allen, D.N., Cross, C.L. (2008). Neurocognitive endophenotypes for bipolar disorder. Bipolar Disorders, 10, 387–399.CrossRefGoogle ScholarPubMed
Gottesman, I.I., Gould, T.J. (2003). The endophenotype concept in psychiatry. Etymology and strategic intentions. The American Journal of Psychiatry, 160, 636–645.CrossRefGoogle ScholarPubMed
Jentsch, J.D., Woods, J.A., Groman, S.M., Seu, E. (2010). Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the balloon analogue risk task. Neuropsychopharmacology, 35, 1797–1806.CrossRefGoogle Scholar
Jollant, F., Guillaume, S., Jaussent, I., Bellivier, F., Leboyer, M., Castelnau, D., Courtet, P. (2007). Psychiatric diagnoses and personality traits associated with disadvantageous decision-making. European Psychiatry, 22, 455–461.CrossRefGoogle ScholarPubMed
Karadag, F., Oral, E.T., Yalcin, F.A., Erten, E. (2002). Validity and reliability of Young Mania Rating Scale in Turkey. Turkish Journal of Psychiatry, 13, 107–114.Google Scholar
Kathleen Holmes, M., Bearden, C.E., Barguil, M., Fonseca, M., Serap Monkul, E., Nery, F.G., Glahn, D.C. (2009). Conceptualizing impulsivity and risk taking in bipolar disorder: Importance of history of alcohol abuse. Bipolar Disorders, 11, 33–40.CrossRefGoogle ScholarPubMed
King, J.A., Tenney, J., Rossi, V., Colamussi, L., Burdick, S. (2003). Neural substrates underlying impulsivity. Annals of the New York Academy of Sciences, 1008, 160–169.CrossRefGoogle ScholarPubMed
Kreek, M.J., Nielsen, D.A., Butelman, E.R., LaForge, K.S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8, 1450–1457.CrossRefGoogle ScholarPubMed
Leigh, B.C. (1999). Peril, chance, and adventure: Concepts of risk, alcohol use, and risky behavior in young adults. Addiction, 94, 371–383.CrossRefGoogle ScholarPubMed
Lejuez, C.W., Aklin, W.M., Bornovalova, M., Moolchan, E.T. (2005). Differences in risk-taking propensity across inner-city adolescent ever- and never-smokers. Nicotine and Tobacco Research, 7(1), 71–79.CrossRefGoogle ScholarPubMed
Lejuez, C.W., Aklin, W.M., Jones, H.A., Richards, J.B., Strong, D.R., Kahler, C.W., Read, J.P. (2003). The Balloon Analogue Risk Task (BART) differentiates smokers and nonsmokers. Experimental and Clinical Psychopharmacology, 11(1), 26–33.CrossRefGoogle ScholarPubMed
Lejuez, C.W., Read, J.P., Kahler, C.W., Ramsey, S.E., Stuart, G.L., Strong, D.R., Brown, R.A. (2002). Evaluation of a behavioral measure of risk taking: The Balloon Analogue Risk Task (BART). Journal of Experimental Psychology (Applied), 8(2), 75–84.CrossRefGoogle ScholarPubMed
Lighthall, N.R., Sakaki, M., Vasunilashorn, S., Nga, L., Somayajula, S., Chen, E.Y., Mather, M. (2011). Gender differences in reward-related decision processing under stress. Social Cognitive and Affective Neuroscience, 7(4), 476–484.CrossRefGoogle ScholarPubMed
Najt, P., Perez, J., Sanches, M., Peluso, M.A., Glahn, D., Soares, J.C. (2007). Impulsivity and bipolar disorder. European Neuropsychopharmacology, 17, 313–320.CrossRefGoogle ScholarPubMed
Özerdem, A., Yazici, O., Oral, E.T., Tunca, Z., Vahip, S., Kurt, E. (2004). The Mood Disorders Study Group Psychiatric Association of Turkey. Establishment of a registry program for bipolar illness in Turkey. Journal of Affective Disorders, 78(Suppl. 1), 86.Google Scholar
Patton, J.H., Stanford, M.S., Barratt, E.S. (1995). Factor structure of the Barratt Impulsiveness Scale. Journal of Clinical Psychology, 51, 768–774.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Peluso, M.A., Hatch, J.P., Glahn, D.C., Monkul, E.S., Sanches, M., Najt, P., Soares, J.C. (2007). Trait impulsivity in patients with mood disorders. Journal of Affective Disorders, 100, 227–231.CrossRefGoogle ScholarPubMed
Rao, H., Korczykowski, M., Pluta, J., Hoang, A., Detre, J.A. (2008). Neural correlates of voluntary and involuntary risk taking in the human brain: An fMRI study of the Balloon Analogue Risk Task (BART). Neuroimage, 42, 902–910.CrossRefGoogle Scholar
Rao, H., Mamikonyan, M.S., Detre, J.A., Siderowf, A.D., Stern, M.B., Potenza, M.N., Weintraub, D. (2010). Decreased ventral striatal activity with impulse control disorders in Parkinson's disease. Movement Disorders, 25, 1660–1669.CrossRefGoogle ScholarPubMed
Ryan, K.K., Mackillop, J., Carpenter, M.J. (2013). The relationship between impulsivity, risk-taking propensity and nicotine dependence among older adolescent smokers. Addictive Behaviors, 38, 1431–1434.CrossRefGoogle ScholarPubMed
Skeel, R.L., Pilarski, C., Pytlak, K., Neudecker, J. (2008). Personality and performance-based measures in the prediction of alcohol use. Psychology of Addictive Behaviors, 22(3), 402–409.CrossRefGoogle ScholarPubMed
Swann, A.C. (2010). Mechanisms of impulsivity in bipolar disorder and related illness. Epidemiologia e Psichiatria Sociale, 19(2), 120–130.CrossRefGoogle ScholarPubMed
Swann, A.C., Anderson, J.C., Dougherty, D.M., Moeller, F.G. (2001). Measurement of inter-episode impulsivity in bipolar disorder. Psychiatry Research, 101(2), 195–197.CrossRefGoogle ScholarPubMed
Swann, A.C., Dougherty, D.M., Pazzaglia, P.J., Pham, M., Moeller, F.G. (2004). Impulsivity: A link between bipolar disorder and substance abuse. Bipolar Disorders, 6, 204–212.CrossRefGoogle ScholarPubMed
Swann, A.C., Dougherty, D.M., Pazzaglia, P.J., Pham, M., Steinberg, J.L., Moeller, F.G. (2005). Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder. The American Journal of Psychiatry, 162(9), 1680–1687.CrossRefGoogle ScholarPubMed
Swann, A.C., Lijffijt, M., Lane, S.D., Steinberg, J.L., Moeller, F.G. (2009). Severity of bipolar disorder is associated with impairment of response inhibition. Journal of Affective Disorders, 116(1–2), 30–36.CrossRefGoogle ScholarPubMed
Swann, A.C., Pazzaglia, P., Nicholls, A., Dougherty, D.M., Moeller, F.G. (2003). Impulsivity and phase of illness in bipolar disorder. Journal of Affective Disorders, 73, 105–111.CrossRefGoogle ScholarPubMed
Stanford, M.S., Mathias, C.W., Dougherty, D.M., Lake, S.L., Anderson, N.E., Patton, J.H. (2009). Fifty years of the Barratt Impulsiveness Scale: An update and review. Personality and Individual Differences, 47(5), 385–395.CrossRefGoogle Scholar
Weafer, J., Milich, R., Fillmore, M.T. (2011). Behavioral components of impulsivity predict alcohol consumption in adults with ADHD and healthy controls. Drug and Alcohol Dependence, 15, 113(2–3), 139–146.CrossRefGoogle ScholarPubMed
White, T.L., Lejuez, C.W., de Wit, H. (2008). Test-retest characteristics of the Balloon Analogue Risk Task (BART). Experimental and Clinical Psychopharmacology, 16, 565–570.CrossRefGoogle ScholarPubMed