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Frailty and dementia: what can the body tell us about the brain?

Published online by Cambridge University Press:  03 June 2021

Kathy Y. Liu Open the ORCID record for Kathy Y. Liu [Opens in a new window]  and
Naaheed Mukadam Open the ORCID record for Naaheed Mukadam [Opens in a new window]
Kathy Y. Liu*
Affiliation:
Division of Psychiatry, University College London, London, UK
Naaheed Mukadam
Affiliation:
Division of Psychiatry, University College London, London, UK
*
Email: kathy.liu@ucl.ac.uk
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Abstract

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Type
Commentary
Information
International Psychogeriatrics , Volume 33 , Special Issue 10: Issue Theme: Non-cognitive Concerns in People with Dementia , October 2021 , pp. 1001 - 1003
Copyright
© International Psychogeriatric Association 2021

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References

Fried, L. P. et al. (2001). Frailty in older adults: evidence for a phenotype. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56, M146–56.CrossRefGoogle ScholarPubMed
Gale, C. R., Westbury, L. and Cooper, C. (2018). Social isolation and loneliness as risk factors for the progression of frailty: the English Longitudinal Study of Ageing. Age and Ageing, 47, 392–397.10.1093/ageing/afx188CrossRefGoogle ScholarPubMed
Gordon, E. H. and Hubbard, R. E. (2020). Differences in frailty in older men and women. The Medical Journal of Australia, 212, 183–188.CrossRefGoogle ScholarPubMed
Graciani, A. et al. (2016). Ideal cardiovascular health and risk of frailty in older adults. Circulation Cardiovascular Quality and Outcomes, 9, 239–245.CrossRefGoogle ScholarPubMed
Kelaiditi, E. et al. (2016). Frailty index and incident mortality, hospitalization, and institutionalization in Alzheimer’s disease: data From the ICTUS Study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 71, 543–548.CrossRefGoogle ScholarPubMed
Livingston, G. et al. (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, 396, 413–446.10.1016/S0140-6736(20)30367-6CrossRefGoogle ScholarPubMed
Ma, Y. et al. (2020). The association between frailty and severe disease among COVID-19 patients aged over 60 years in China: a prospective cohort study. BMC Medicine, 18, 274.CrossRefGoogle ScholarPubMed
Mitnitski, A. B., Mogilner, A. J. and Rockwood, K. (2001). Accumulation of deficits as a proxy measure of aging. The Scientific World Journal, 1, 323–336.10.1100/tsw.2001.58CrossRefGoogle ScholarPubMed
Mukadam, N. et al. (2020). Effective interventions for potentially modifiable risk factors for late-onset dementia: a costs and cost-effectiveness modelling study. The Lancet Healthy Longevity, 1, e13–e20.CrossRefGoogle Scholar
Nelson, P. T. et al. (2019). Limbic-Predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain: A Journal of Neurology, 142, 1503–1527.CrossRefGoogle ScholarPubMed
Partridge, J. S. L., Harari, D. and Dhesi, J. K. (2012). Frailty in the older surgical patient: a review. Age and Ageing, 41, 142–147.CrossRefGoogle ScholarPubMed
Petermann-Rocha, F. et al. (2020). Associations between physical frailty and dementia incidence: a prospective study from UK Biobank. The Lancet Healthy Longevity, 1, e58–e68.CrossRefGoogle Scholar
Rockwood, K., Andrew, M. and Mitnitski, A. (2007). A comparison of two approaches to measuring frailty in elderly people. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62, 738–743.CrossRefGoogle ScholarPubMed
Searle, S. D. et al. (2008). A standard procedure for creating a frailty index. BMC Geriatrics, 8, 24.10.1186/1471-2318-8-24CrossRefGoogle ScholarPubMed
Sommerlad, A. et al. (2019). Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study. PLoS Medicine, 16, e1002862.10.1371/journal.pmed.1002862CrossRefGoogle ScholarPubMed
Soysal, P. et al. (2016). Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Research Reviews, 31, 1–8.10.1016/j.arr.2016.08.006CrossRefGoogle ScholarPubMed
Sweeney, M. D. et al. (2019). Vascular dysfunction-The disregarded partner of Alzheimer’s disease. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 15, 158–167.10.1016/j.jalz.2018.07.222CrossRefGoogle ScholarPubMed
Theou, O. et al. (2012). Disability and co-morbidity in relation to frailty: how much do they overlap?. Archives of Gerontology and Geriatrics, 55, e1–8.10.1016/j.archger.2012.03.001CrossRefGoogle ScholarPubMed
Van der Elst, M. et al. (2018). Interventions for frail community-dwelling older adults have no significant effect on adverse outcomes: a systematic review and meta-analysis. BMC Geriatrics, 18, 249.CrossRefGoogle ScholarPubMed
Wallace, L. et al. (2021). Frailty and neuropathology in relation to dementia status: The Cambridge City over-75s Cohort study. International Psychogeriatrics. doi: 10.1017/S1041610220003932 CrossRefGoogle Scholar
Wyss-Coray, T. and Rogers, J. (2012). Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harbor Perspectives in Medicine, 2, a006346.10.1101/cshperspect.a006346CrossRefGoogle ScholarPubMed