Hostname: page-component-848d4c4894-p2v8j Total loading time: 0 Render date: 2024-04-30T22:55:41.724Z Has data issue: false hasContentIssue false
  • English
  • Français

p-Chloroamphetamine treatment modifies evoked responses to sinusoidal gratings in the pigeon optic tectum

Published online by Cambridge University Press:  02 June 2009

R. Alesci ,
V. Porciatti ,
L. Sebastiani  and
P. Bagnoli
R. Alesci
Affiliation:
Department of Physiology and Biochemistry, Universtiy of Pisa, Italy
V. Porciatti
Affiliation:
Institute of Neurophysiology, C.N.R., Pisa, Italy
L. Sebastiani
Affiliation:
Department of Physiology and Biochemistry, Universtiy of Pisa, Italy
P. Bagnoli
Affiliation:
Department of Physiology and Biochemistry, Universtiy of Pisa, Italy
Get access Rights & Permissions [Opens in a new window]

Abstract

This study was performed in order to establish whether selective depletion of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the pigeon optic tectum (TeO) induced by p-chloroamphetamine (p-CA) modified tectal evoked potentials (TEPs). TEPs in response to sinusoidal gratings of different contrast, spatial and temporal frequency were recorded in control pigeons and in pigeons intraperitoneally injected with p-CA (10 mg/kg; two administrations in consecutive days). TEPs of p-CA treated pigeons, as compared to those of control pigeons, were reduced in amplitude as a function of contrast, spatial and temporal frequency. In addition, TEPs of p-CA treated pigeons differed from those recorded in controls in their transfer characteristics of contrast and spatial frequency. In particular, TEPs of p-CA treated pigeons did not saturate at moderate contrast, unlike those of controls. Furthermore, the TEP spatial tuning in p-CA treated pigeons is broader than that in controls; it thus suggests a reduction of spatial-frequency selectivity. These findings indicate that a selective neurotoxin for serotonergic systems, such as p-CA, can serve as a useful denervation tool for the study of the serotonergic function in the pigeon TeO. In addition, selective changes of TEP properties suggest the possibility that serotonergic afferents play a modulatory role on the receptive-field characteristics of tectal neurons.

Keywords

Pattern evoked potentialsOptic tectump-chloroamphetamineSerotonin depletionPigeon
Type
Research Articles
Information
Visual Neuroscience , Volume 2 , Issue 2 , February 1989 , pp. 147 - 152
Copyright
Copyright © Cambridge University Press 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alesci, R. & Bagnoli, P. (1988). Endogenous levels of serotonin and 5-hydroxyindoleacetic acid in specific areas of the pigeon C.N.S.: effect of serotonin neurotoxins. Brain Research 50 259–271.Google Scholar
Bagnoli, P., Barsellotti, R., Pellegrini, M. & Alesci, R. (1983). Norepinephrine levels in developing pigeon brain: effect of monocular deprivation on the Wulst noradrenergic system. Developmental Brain Research 10, 243–250.Google Scholar
Bagnoli, P. & Casini, G. (1985). Regional distribution of catecholaminergic terminals in the pigeon visual system. Brain Research 337, 277–286.CrossRefGoogle Scholar
Bagnoli, P., Francesconi, W. & Pellegrino, M. (1981). Contrast sensitivity of neurons in pigeon optic tectum. Brain Research 223, 39–48.CrossRefGoogle Scholar
Bagnoli, P., Grassi, S. & Magni, F. (1980). A direct connection between visual Wulst and tectum opticum in the pigeon (Columbalivia) demonstrated by horseradish peroxidase. Archives Italien de Biologie 118 72–88.Google Scholar
Bagnoli, P., Porciatti, V. & Francesconi, W. (1985). Retinal and tectal responses to alternating gratings are unaffected by monocular deprivation in pigeons. Brain Research 338, 341–345.Google Scholar
Beart, P.M. (1976). An evaluation of L-glutamate as the transmitter released from optic nerve terminals of the pigeon. Brain Research 110, 99–114.Google Scholar
Brecha, N.C. (1978). Some observations of the organization of the avian optic tectum: afferent nuclei and their tectal projections. Unpublished Thesis, State University of New York, Stony Brook.Google Scholar
Brecha, N.C., Hunt, S.P. & Karten, H.J. (1976). Relations between the optic tectum and basal ganglia in the pigeon. Society for Neuroscience Abstracts 2, 1069.Google Scholar
Cajal, S.R. (1911). Histologie du Systeme Nerveux de I'homme et des Vertebres, Vol. 2. Paris: Maloine.Google Scholar
Clarke, P.G.H. & Whitteridge, D. (1976). The projection of the retina, ina, including the “red area,” onto the optic tectum of the pigeon. Quarterly Journal of Experimental Physiology 61, 351–358.CrossRefGoogle Scholar
Cuenod, N. & Henke, H. (1978). Neurotransmitters in the avian visual system. In Amino Acids as Chemical Transmitters, ed. Fonnum, F., pp. 221–239. New York: Plenum Press.Google Scholar
De Lima, A.D. & Singer, W. (1987). The serotonergic fibers in the dorsal lateral geniculate nucleus of the cat: distribution and synaptic connections demonstrated with immunocytochemistry. Journal of Comparative Neurology 258, 339–351.Google Scholar
Haigler, H.J. & Aghajanian, G.K. (1974). Lysergic acid diethylamide and serotonin: a comparison of effects on serotonergic neurons and neurons receiving a serotonergic input. Journal of Pharmacology and Experimental Therapeutics 188, 688–699.Google Scholar
Hardy, O., Leresche, N. & Jassik-Gerschenfeld, D. (1982). The spatial organization of the excitatory regions in the visual receptive field of the pigeon's optic tectum. Experimental Brain Research 46, 59–68.CrossRefGoogle ScholarPubMed
Henke, H., Schenker, T.M. & Cuenod, M. (1976). Uptake of neurotransmitter candidates by pigeon optic tectum. Journal of Neurochemistry 26, 125–130.Google Scholar
Hodos, W. (1976). Vision and the visual system: a bird's eye view. In Progress in Psychobiology and Physiological Psychology, Vol. 6, ed. sprague, J.M. & Epstein, A.N., pp. 29–62. New York: Academic Press.Google Scholar
Hull, C.H. & Nie, N.H. (1981). SPSS Update: New Procedures and Facilities for Releases 7–9. New York: McGraw-Hill.Google Scholar
Hunt, S.P. & Kunzle, M. (1976). Bidirectional movement of label and transneuronal transport phenomena after injection of (3H) adenosine into the central nervous system. Brain Research 112, 127–132.Google Scholar
Hunt, S.P., Streit, P., Kunzle, M. & Cuenod, M. (1977). Characterization of the pigeon isthmo-tectal pathway by selective uptake and retrograde movement of radioactive compounds and by Golgilike horseradish peroxidase labeling. Brain Research 129, 197–212.CrossRefGoogle Scholar
Jassik-Gerschenfeld, D. & Hardy, O. (1984). The avian optic tectum: neurophysiology and behavioral correlations. In Comparative Neurology of the Optic Tectum, ed. Vanegas, H., pp. 649–686. New York and London: Plenum Press.Google Scholar
Jonsson, G. (1983). Chemical lesioning techniques: monoamine neurotoxins. In Handbook of Chemical Neuroanatomy, Vol. I: Methods in Chemical Neuroanatomy, ed. Bjorklund, A. & Hokfelt, T., pp. 463–507. Amsterdam: Elsevier.Google Scholar
Juorio, A.V. & Vogt, M. (1967). Monoamines and their metabolites in the avian brain. Journal of Physiology (London) 189, 489–518.Google Scholar
Karten, H.J., Hodos, W., Nauta, W.J. & Revzin, A.M. (1973). Neural connections of the “visual Wulst” of the avian telencephalon. Experimental studies in the pigeon (Columba livia) and owl (Speotyto cunicularia). Journal of Comparative Neurology 150, 253–278.Google Scholar
Kemp, J.A., Roberts, H.C. & Sillito, A.M. (1982). Further studies on action of 5-hydroxytryptamine in the dorsal lateral geniculate nucleus of the cat. Brain Research 246, 334–337.CrossRefGoogle Scholar
Kilts, C.D., Breese, G.R. & Mallman, R.B. (1981). Simultaneous quantification of dopamine, 5-hydroxytryptamine and four metabolically related compounds by means of reversed-phase high-performance liquid chromatography with electrochemical detection. Journal of Chromatography 225, 347–357.Google Scholar
Leresche, N., Hardy, O & Jassik-Gerschenfeld, D. (1983). Receptive-field properties of single cells in the pigeon's optic tectum during cooling of the “Visual Wulst”. Brain Research 267, 225–236.Google Scholar
Leresche, N., Hardy, O. & Jassik-Gerschenfeld, D. (1984). Suppressive regions in the visual receptive fields of single cells of the pigeon's optic tectum. Experimental Brain Research 53, 327–334.Google Scholar
Livingstone, M.S. & Hubel, D.H. (1981). Effects of sleep and arousal on the processing of visual information in the cat. Nature 291 554–561.CrossRefGoogle ScholarPubMed
Marks, G.A., Speciale, S.G., Cobbey, K. & Roffwarg, H.P. (1987). Serotonergic inhibition of the dorsal lateral geniculate nucleus. Brain Research 418, 76–84.Google Scholar
Miceli, D., Gioanni, H., Reperant, J. & Peyrichoux, J. (1979). The avian visual Wulst. I. An anatomical study of afferent and efferent pathways. II. An electrophysiological study of the functional properties of single neurons. In Neural Mechanism of Behavior in the Pigeon, ed. Granda, A.M. & Maxwell, J.H., pp. 223–254. New York: Plenum Press.Google Scholar
Padmos, P., Haauman, J.J. & Spekreuse, H. (1973). Visually evoked cortical potentials to patterned stimuli in monkey and man. Electroencephalography and Clinical Neurophysiology 35, 153–163.Google Scholar
Porciatti, V., Alesci, R. & Bagnoli, P. (1989). Evoked responses to sinusoidal gratings in the pigeon optic tectum. Visual Neuroscience 2, 137–145.Google Scholar
Porciatti, V., Bagnoli, P. & Alesci, R. (1987). ON and OFF activity in the retinal and tectal responses to focal stimulation with uniform or patterned stimuli. Clinical Vision Sciences 2, 93–102.Google Scholar
Rogawski, M.A. & Aghajanian, G.K. (1980). Norepinephrine and serotonin: opposite effects on the activity of lateral geniculate neurons evoked by optic pathway stimulation. Experimental Neurology 69, 678–694.Google Scholar
Steinbusch, H.W.M. (1981). Distribution of serotonin–immunoreactivity in the central nervous system of the rat. Cell bodies and terminals. Neuroscience 6, 557–618.CrossRefGoogle Scholar
Straschill, M. & Perwein, J. (1971). Effect of iontophoretically applied biogenic amines and of cholinomimetic substances upon the activity of neurons in the superior colliculus and mesencephalic reticular formation of the cat. Pflugers Archives 324, 43–55.Google Scholar
Ueda, S. & Sano, Y. (1986). Distributional pattern of serotonin immunoreactive nerve fibers in the lateral geniculate nucleus of the rat, cat, and monkey (Macaca fuscata). Cell and Tissue Research 243, 249–253.Google Scholar
Vischer, A., Henke, H. & Cuenod, M. (1982). Neurotransmitter receptor ligand binding and enzyme regional distribution in the pigeon. Journal of Neurochemislry 38, 1372–1382.Google Scholar
Voneida, T.J. & Mello, N.K. (1975). Interhemispheric projections of the optic tectum in pigeon. Brain Behavior and Evolution 11, 91–108.Google Scholar
Webster, K.E. (1974). Changing concepts on the central visual pathways in birds. In Essays on the Nervous System, ed. Bellairs, R. & Gray, E.G., pp. 258–298. Oxford: Clarendon Press.Google Scholar
Yamada, H. & Sano, Y. (1985). Immunohistochemical studies on the serotonin neuron system in the brain of the chicken (Gallus domesticus). II. The distribution of nerve fibers. Biogenic Amines 2, 21–36.Google Scholar