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Facilitation of Kindled Seizures in Rats Fed Choline-Supplemented Diets

Published online by Cambridge University Press:  18 September 2015

Kevin McCann ,
Donald P. Cain  and
Diana J. Philbrick
Kevin McCann
Affiliation:
Departments of Psychology and Physiology, University of Western Ontario, London, Ontario
Donald P. Cain*
Affiliation:
Departments of Psychology and Physiology, University of Western Ontario, London, Ontario
Diana J. Philbrick
Affiliation:
Departments of Psychology and Physiology, University of Western Ontario, London, Ontario
*
Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2.
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Different groups of rats were maintained on choline-deprived (CD), choline-supplemented (CS) or standard rat chow diets beginning at a body weight of approximately 100 g, and electrically kindled in the amygdala beginning not less than 40 days later. The CS group kindled significantly faster than the CD group, whereas the CD and chow-fed groups did not differ in their rate of kindling. This result is consistent with both the known effects of the dietary manipulation of choline on brain acetylcholine level, and the idea that acetylcholine has a role in amygdaloid kindling.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 10 , Issue 1 , February 1983 , pp. 47 - 49
Copyright
Copyright © Canadian Neurological Sciences Federation 1983

References

Bartus, R.T., Dean, R.L. III, Beer, B. and Lippa, A.S. (1982). The cholinergic hypothesis of geriatric memory dysfunction. Science, 217, 408–417.CrossRefGoogle ScholarPubMed
Cain, D.P. (1983). Bidirectional transfer of electrical and carbachol kindling. Brain Res., in press.CrossRefGoogle Scholar
Cohen, E.L. and Wurtman, R.J. (1976). Brain acetylcholine: Control by dietary choline. Science, 191, 561–562.CrossRefGoogle ScholarPubMed
Davis, K.L., Berger, P.A. and Hollister, L.E. (1975). Choline for tardive dyskinesia. N. Eng. J. Med., 293, 152.Google ScholarPubMed
Fernstrom, M.H. (1981). Lecithin, choline, and cholinergic transmission. In Spiller, G.A. (Ed.) Current Topics in Nutrition and Disease. Vol. 4. Nutritional Pharmacology. A.R. Liss, N.Y., 1981, 5–29.Google Scholar
Goddard, G.V. (1969). Analysis of avoidance conditioning following cholinergic stimulation of amygdala in rats. J. Comp. Physiol. Psychol. Monogr. 68, no. 2, part 2, 1–18.CrossRefGoogle ScholarPubMed
Haubrich, D.R., Wang, P.F.L., Chippendale, T. and Proctor, E. (1976). Choline and acetylcholine in rats: Effect of dietary choline. J. Neurochem., 27, 1305–1313.CrossRefGoogle ScholarPubMed
Mason, C.R. and Cooper, R.M. (1972). A permanent change in convulsive threshold in normal and braindamaged rats with repeated small doses of pentylenetetrazol. Epilepsia, 13, 663–674.Google ScholarPubMed
Post, R.M., Kopanda, R.T. and Black, K.E. (1976). Progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: Relationship to kindling and psychosis. Biol. Psychiat., 11, 403–419.Google ScholarPubMed
Racine, R.J. (1972). Modification of seizure activity by electrical stimulation: II. Motor seizure. Electro-encephalog. Clin. Neurophysiol., 32, 281–294.Google Scholar
Racine, R.J. (1978). Kindling: The first decade. Neurosurg. 3, 234–251.CrossRefGoogle ScholarPubMed
Vosu, H. and Wise, R.A. (1975). Cholinergic kindling in the rat: Comparison of caudate, amygdala and hippocampus. Behav. Biol., 13, 492–495.CrossRefGoogle ScholarPubMed