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Progression and Outcome of Patients in a Canadian Dementia Clinic

Published online by Cambridge University Press:  18 September 2015

David B. Hogan ,
Daniel E. Thierer ,
Erika M. Ebly  and
Irma M. Parhad
David B. Hogan*
Affiliation:
Departments of Medicine. Clinical Ncurosciences and Pathology. University of Calgary, Calgary
Daniel E. Thierer
Affiliation:
Departments of Medicine. Clinical Ncurosciences and Pathology. University of Calgary, Calgary
Erika M. Ebly
Affiliation:
Departments of Medicine. Clinical Ncurosciences and Pathology. University of Calgary, Calgary
Irma M. Parhad
Affiliation:
Departments of Medicine. Clinical Ncurosciences and Pathology. University of Calgary, Calgary
*
University of Calgary, Health Sciences Centre, 3330 Hospital Drive N.W.. Calgary, Alberta. Canada T2N 4NI
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Abstract:

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Five hundred and fifty-three patients were referred to a Canadian dementia clinic for standardized evaluation. The majority (83.5%) had a dementia with Alzheimer’s disease (AD) accounting for 89% of dementias. Patients with probable AD who were followed for five years had variable rates of progression, increased mortality (37.1%, 2.5 times the expected rate) and a high rate of institutionalization (79%). Simple demographic (age) and social factors (marital status) were strong predictors for institutionalization. It was extremely difficult at presentation to predict the rate of progression. The prevalence of AD in autopsied cases was 62.5%. Clinic patients were younger, had milder dementias, and were more likely to have AD than patients identified in the course of a contemporaneous population-based dementia prevalence study.

Résumé:

Résumé:

Progression et devenir des patients référés dans une clinique canadienne de démence. Cinq cent cinquante-trois patients ont été référés à une clinique canadienne de démence pour subir une évaluation standardisée. La majorité (83.5%) avaient une démence et 89% des démences étaient dues à la maladie d’Alzheimer. Les patients avec maladie d’Alheimer probable, qui ont été suivis pendant cinq ans, avaient des taux variables de progression, une mortalité plus élevée (37.1%, soit 2.5 fois le taux attendu) et un taux élevé d’institutionnalisation (79%). Des facteurs démographiques (l’âge) et sociaux (l’état matrimonial) simples étaient des prédicteurs puissants de l’institutionnalisation. Il était extrêmement difficile à l’évaluation initiale de prédire le taux de progression. La prévalence de la maladie d’Alzheimer chez les cas ayant subi une autopsie était de 62.5%. Les patients de la clinique étaient plus jeunes, avaient une démence moins sévère et étaient plus susceptibles d’avoir la maladie d’Alzheimer que les patients identifiés lors d’une étude de population concomitante étudiant la prévalence de la démence.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 21 , Issue 4 , November 1994 , pp. 331 - 338
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

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