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Neuronal Migration Disorders: A Contribution of Modern Neuroimaging to the Etiologic Diagnosis of Epilepsy

Published online by Cambridge University Press:  18 September 2015

André Palmini ,
Frederick Andermann ,
André Olivier ,
Donatella Tampieri ,
Yvon Robitaille ,
Denis Melanson  and
Romeo Ethier
André Palmini
Affiliation:
Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute and Hospital, Montreal
Frederick Andermann*
Affiliation:
Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute and Hospital, Montreal
André Olivier
Affiliation:
Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute and Hospital, Montreal
Donatella Tampieri
Affiliation:
Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute and Hospital, Montreal
Yvon Robitaille
Affiliation:
Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute and Hospital, Montreal
Denis Melanson
Affiliation:
Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute and Hospital, Montreal
Romeo Ethier
Affiliation:
Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute and Hospital, Montreal
*
Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
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Abstract:

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Computed tomography and magnetic resonance imaging enable the identification of neuronal migration disorders during life. Several specific syndromes have been identified and early diagnosis of previously unrecognized entities is now possible. We report 51 patients with imaging. Thirty-two had a single widespread cortical dysplastic lesion. Twenty-eight had focal corticectomies. From a pathological standpoint, these encompassed focal cortical dysplasia (14 cases) and forme fruste of tuberous sclerosis (10 cases). These two groups of patients were indistinguishable from the clinical and radiological standpoint. In only two was the MRI examination normal. In addition, there were 10 with bilateral perisylvian dysplasia, four with diffuse cortical dysplasia or the "double cortex" syndrome, three with hemimegalencephaly, one with megalencephaly, and one with nodular neuronal heterotopia. The electroclinical and imaging findings led to the development of specific surgical strategies for the alleviation of the intractable seizures in each of these radiologically-defined syndromes.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S4 , November 1991 , pp. 580 - 587
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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