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Alzheimer's Disease: Environmental Factors and Etiologic Hypotheses

Published online by Cambridge University Press:  18 September 2015

Denyse Gautrin  and
Serge Gauthier
Denyse Gautrin
Affiliation:
McGill Centre for Studies in Aging, McGill University, Montreal INRS - Santé
Serge Gauthier*
Affiliation:
McGill Centre for Studies in Aging, McGill University, Montreal
*
1650 Cedar Ave, Montreal, Quebec, Canada H3G 1A4
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Abstract:

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A review of published reports on conventional and unconventional viruses, aluminum, neurotoxic metals and trace elements, neurotoxins of biological origin and immune systems, suggest that environmental factors, possibly multiple ones, play a significant role in the etiology of Alzheimer's disease. A complex interaction between genetic predisposition to this illness, natural aging processes, environmental factors over a life-time exposure and pathological alterations of the host immune system is proposed.

Résumé:

RÉSUMÉ:

Notre revue des rapports publiés sur les virus conventionnels et non-conventionnels, l'aluminium, les métaux neurotoxiques et éléments rares, les neurotoxines biologiques et les systèmes immunitaires, suggère que des facteurs environnementaux, possiblement multiples, jouent un rôle significatif dans l'étiologie de la maladie d'Alzheimer. Une interaction complexe entre une prédisposition génétique à cette maladie, les mécanismes du vieillissement naturel, les facteurs environmentaux au cours de la vie et des changements pathologiques du système immunitaire de l'hôte est proposée.

Type
Review Article
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 4 , November 1989 , pp. 375 - 387
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

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