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Limbic cortico-striato-thalamo-cortical functional connectivity in drug-naïve patients of obsessive-compulsive disorder

Published online by Cambridge University Press:  23 October 2019

Qing Zhao ,
Tingting Xu ,
Yuan Wang ,
Dandan Chen ,
Qiang Liu ,
Zhi Yang  and
Zhen Wang Open the ORCID record for Zhen Wang [Opens in a new window]
Qing Zhao
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
Tingting Xu
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
Yuan Wang
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
Dandan Chen
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
Qiang Liu
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
Zhi Yang*
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China Shanghai Key Laboratory of Psychotic Disorders, Shanghai, P.R. China Institute of Psychological and Behavioral Science, Shanghai Jiao Tong University, Shanghai, China Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China
Zhen Wang*
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China Shanghai Key Laboratory of Psychotic Disorders, Shanghai, P.R. China Institute of Psychological and Behavioral Science, Shanghai Jiao Tong University, Shanghai, China
*
Author for correspondence: Zhi Yang, E-mail: yangzhi_psy@126.com and Zhen Wang, E-mail: wangzhen@smhc.org.cn
Author for correspondence: Zhi Yang, E-mail: yangzhi_psy@126.com and Zhen Wang, E-mail: wangzhen@smhc.org.cn
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Abstract

Background

The pathophysiology of obsessive-compulsive disorder (OCD) remains unclear despite extensive neuroimaging work on the disorder. Exposure to medication and comorbid mental disorders can confound the results of OCD studies. The goal of this study was to explore differences in brain functional connectivity (FC) within the cortico-striato-thalamo-cortical (CSTC) loop of drug-naïve and drug-free OCD patients and healthy controls (HCs).

Methods

A total of 29 drug-naïve OCD patients, 22 drug-free OCD patients, and 25 HCs matched on age, gender and education level underwent functional magnetic resonance imaging scanning at resting state. Seed-based connectivity analyses were conducted among the three groups. The Yale Brown Obsessive Compulsive Scale and clinical inventories were used to assess the clinical symptoms.

Results

Compared with HCs, the drug-naïve OCD patients had reduced FC within the limbic CSTC loop. In the drug-naïve OCD participants, we also found hyperconnectivity between the supplementary motor area and ventral and dorsal putamen (p < 0.05, corrected for multiple comparisons).

Conclusions

Exposure to antidepressants such as selective serotonin reuptake inhibitors may affect the function of some brain regions. Future longitudinal studies could help to reveal the pharmacotherapeutic mechanisms in these loops.

Keywords

Functional connectivityfunctional magnetic resonance imagingobsessive-compulsive disorderselective serotonin reuptake inhibitor
Type
Original Articles
Information
Psychological Medicine , Volume 51 , Issue 1 , January 2021 , pp. 70 - 82
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Copyright
Copyright © Cambridge University Press 2019

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Footnotes

*

These authors contributed equally to this work and should be considered as co-first authors.

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