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Iron overload increases hepatic development of Plasmodium yoelii in mice
Published online by Cambridge University Press: 26 March 2010
Summary
Iron overload in BALB/c mice by treatment with ferric ammonium citrate promotes the hepatic development of Plasmodium yoelii in vivo and in vitro. This was the result of increased penetration of the parasite into hepatocytes since no effect was observed on parasite transformation or maturation. These results could explain why in endemic regions iron supplementation led, in certain studies, to an increase in clinical episodes of malaria and in the prevalence of malaria infection.
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- Copyright © Cambridge University Press 1996
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