Hostname: page-component-76fb5796d-45l2p Total loading time: 0 Render date: 2024-04-25T13:33:08.767Z Has data issue: false hasContentIssue false
  • English
  • Français

Transplantation of adult Trichinella spiralis between hosts: worm survival and immunological characteristics of the host–parasite relationship

Published online by Cambridge University Press:  06 April 2009

M. W. Kennedy ,
D. Wakelin  and
Margaret M. Wilson
M. W. Kennedy
Affiliation:
Department of Zoology and Wellcome Laboratories for Experimental Parasitology, University of Glasgow
D. Wakelin
Affiliation:
Department of Zoology and Wellcome Laboratories for Experimental Parasitology, University of Glasgow
Margaret M. Wilson
Affiliation:
Department of Zoology and Wellcome Laboratories for Experimental Parasitology, University of Glasgow
Get access Rights & Permissions [Opens in a new window]

Summary

A technique for the transplantation of Trichinella spiralis worms directly into the host intestine is described. Infections established by the direct transfer of adult worms were essentially normal both in terms of their survival and reproduction and in their stimulation of, and susceptibility to, host immune responses. Worms transplanted from NIH mouse donors at intervals after infection had an equal ability to survive in the recipient, even when taken from the donor shortly before or during the process of worm expulsion, showing that expulsion does not require worms to be irreversibly damaged. It was noted, however, that after 7 days in the donor the ability of the worm to reproduce in the recipient was temporarily impaired.

Type
Research Article
Information
Parasitology , Volume 78 , Issue 2 , April 1979 , pp. 121 - 130
Copyright
Copyright © Cambridge University Press 1979

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Alphey, T. J. W. (1970). Studies on the distribution and site location of Nippostrongylus brasiliensis within the small intestine of laboratory rats. Parasitology 61, 449–60.CrossRefGoogle ScholarPubMed
Anderson, C. V. & Leonard, A. B. (1940). Immunity produced in rats by the intestinal phase of Trichinella infection. Journal of Parasitology 26 (Suppl.), 42–3.Google Scholar
Denham, D. A. (1966). Immunity to Trichinella spiralis. II. Immunity produced by the adult worm in mice. Parasitology 56, 745–51.CrossRefGoogle ScholarPubMed
Fatunmbi, O. O. (1978). Studies on some aspects of the development of Trichinella spiralis in mice. M.Sc. thesis, University of Glasgow.Google Scholar
Hopkins, C. A. & Zajac, A. (1976). Transplantation of Hymenolepis diminuta into naive, immune and irradiated mice. Parasitology 73, 73–81.CrossRefGoogle ScholarPubMed
Howard, R. J. (1977). Hymenolepis microstoma: a change in susceptibility to resistance with increasing age of the parasite. Parasitology 75, 241–9.CrossRefGoogle ScholarPubMed
Katz, F. F. (1960). The oral transplantation of intestinal stages of Trichinella spiralis. Journal of Parasitology 46, 500–4.CrossRefGoogle ScholarPubMed
Kennedy, M. W. (1976). Kinetics of establishment and rejection of the enteral phase of a primary infection of Trichinella spiralis in the NIH strain mouse. Transactions of the Royal Society of Tropical Medicine and Hygiene 70, 285.Google Scholar
Matoff, K. (1963). On the transplantation of young intestinal trichinellae. Zeitschrift für Parasitenkunde 22, 6, 495–513.Google Scholar
Mougeot, G. & Lancastre, F. (1973). Experimental trichinosis. III. Intestinal transplantations of adult Trichinella spiralis. Annales de parasitologie humaine et comparée 48, 55–9.CrossRefGoogle Scholar
Ogilvie, B. M. & Love, R. J. (1974). Co-operation between antibodies and cells in immunity to a nematode parasite. Transplantation Reviews 56, 745–51.Google Scholar
Pawlowski, Z. & Rauhut, W. (1971). Transplantation of Trichinella spiralis in rats. Wiadomosci Parazytologiczne XVII (56), 497–501.Google Scholar
Rothwell, T. L. W., Prichard, R. K. & Love, R. J. (1974). Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. I. In vivo and in vitro effects of the amines. International Archives of Allergy and Applied Immunology 46, 1–13.CrossRefGoogle ScholarPubMed
Wakelin, D. & Lloyd, M. (1976). Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters. Parasitology 72, 173–82.CrossRefGoogle ScholarPubMed
Wakelin, D. & Wilson, M. M. (1977). Evidence for the involvement of a bone marrow-derived cell population in the immune expulsion of Trichinella spiralis. Parasitology 74, 225–34.CrossRefGoogle ScholarPubMed