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Value of autofluorescence bronchoscopy in patients with laryngeal cancer

Published online by Cambridge University Press:  09 November 2010

E Çetınkaya
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
B Veyseller
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
Y S Yildirim*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
F Aksoy
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey
M A Özgül
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
A Gençoğlu
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
S Altin
Affiliation:
Department of Chest Disease, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
*
Dr Yavuz Selim Yıldırım, Haseki Egitim ve Arastirma Hastanesi, Kulak Burun Bogaz Klinigi, 34089 Fatih, Istanbul, Turkey Fax: +90 212 5103701 E-mail: dryavuzselim@yahoo.com

Abstract

Background:

Patients with squamous cell carcinoma of the head and neck constitute a high risk group for synchronous and metachronous tumours.

Objective:

This study aimed to investigate the usefulness of white light and autofluorescence bronchoscopy in the evaluation of pre-malignant and early neoplastic lesions in patients with laryngeal cancer, who are at high risk of concomitant lung cancer.

Methods:

This prospective, cross-sectional study included 30 patients who had undergone total laryngectomy for squamous cell carcinoma of the larynx. The tracheobronchial system was investigated for the presence of pre-malignant and malignant lesions, using a combination of white light and autofluorescence bronchoscopy. Biopsies were obtained from areas with a pathological appearance, and histopathological studies were performed.

Results:

All patients had a permanent tracheostomy. Light and autofluorescence bronchoscopy indicated that the tracheobronchial system was normal in 11 patients. A total of 27 biopsies was taken from the remaining 19 patients, and revealed invasive squamous cell carcinoma in one patient and pre-malignant changes in six.

Conclusion:

Bronchoscopy is a valuable and practical tool for screening patients at high risk of lung cancer, and requires minimal intervention especially in patients with a permanent tracheostomy. Of the various bronchoscopic techniques becoming available, autofluorescence bronchoscopy shows promise for the detection of pre-invasive malignant changes of the tracheobronchial system in patients previously operated upon for laryngeal cancer.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2010

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