We have experimentally examined the effects of a common soluble surfactant on gas bubbles in liquid flows in inclined tubes. Air bubbles of known size (λ = 0.8, 1.0, 1.5) are held stationary under minimum flow conditions in tubes inclined at fixed angles (ω = 25°, 45°, 65°, 90°). Sodium dodecyl sulphate (SDS) is infused into the bulk flow at two bulk concentrations (C = 10% or 100% critical micelle concentration (CMC)). In addition to recording pressure and flow waveforms, we capture video images of bubbles before and during exposure to the surfactant. Modification of the interfacial properties by the surfactant results in extremely dynamic bubble behaviour including interfacial deformation, deformation plus axial translation, and bubble detachment from the wall plus translation. We measure the corresponding time-dependent pressure gradient within the tube. The surfactant mediated responses observed are dependent upon the interrelated effects of C, λ and ω. A high bulk concentration of surfactant may produce more rapid modification of bubble shape and influence wetting, thus increasing the potential for bubble detachment. The likelihood that detachment will occur increases further as bubble volume in increased. In both vertical tubes in which contact forces are absent and in non-vertical tubes, the infusion of surfactant may result in axial translation either in the direction of, or opposite to, the direction of the bulk flow. Critical to the translation and/or detachment of the bubble is the surfactant-mediated modification of contact line mechanics. Contact line velocities corresponding to rates of shrinkage of dewetted surface area are extracted from experimental data. We also explore the potential effects of surfactants on interfacial remobilization. This investigation demonstrates the potential use of surfactants to be used for dislodging dewetted gas bubbles by the intentional manipulation of interfacial properties.