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Identification of a variant growth hormone haplotype in mice selected for high body weight

Published online by Cambridge University Press:  14 April 2009

R. Keith Salmon ,
Roy T. Berg ,
Francis C. Yeh  and
Ross B. Hodgetts
R. Keith Salmon*
Affiliation:
Department of Animal ScienceUniversity of Alberta, Edmonton, Alberta, Canada T6G 2P5
Roy T. Berg
Affiliation:
Department of Animal ScienceUniversity of Alberta, Edmonton, Alberta, Canada T6G 2P5
Francis C. Yeh
Affiliation:
Department of Forest ScienceUniversity of Alberta, Edmonton, Alberta, Canada T6G 2P5
Ross B. Hodgetts
Affiliation:
Department of Genetics, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
*
* Corresponding author.

Summary

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Restriction site analysis revealed a variant growth hormone gene haplotype fixed within growth-selected mice (High line-3; HL-3) exhibiting growth rates 1·5 times greater than those of unselected Foundation population (FP-3) mice. Relative to the FP-3 haplotype, the HL-3 haplotype exhibited restriction fragment length polymorphisms for each of seven different restriction enzymes. Three of the polymorphic sites lie within 1·1 kb of the 5′ end of the structural gene; a fourth polymorphism exists within the structural gene. The HL-3 haplotype was also fixed within an additional three growth-selected lines (including a replicate of HL-3). This identification of an association, between the natural variant of a growth regulating gene and a growth-related phenotype, is the prototype of experiments that could lead to the isolation of variant genes which enhance livestock production characters.

Type
Research Article
Information
Genetics Research , Volume 52 , Issue 1 , August 1988 , pp. 7 - 15
Copyright
Copyright © Cambridge University Press 1988

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