Human T-cell receptor β-chain genes

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Summary

cDNA clones encoding the β chain of the T-cell antigen receptor from the human leukaemic cell line JM (which extend through the constant region and into the variable region of the receptor) show hybridization only to RNA from JM cells, and not in five other T-cell leukaemias. Multiple hybridizing bands were detected in genomic DNA digests by a Vβ probe, suggesting that inherited Vβ gene diversity will be significant.

Two β-chain constant region genes (designated Cβ1 and Cβ2) occur inhuman genomic DNA, and both of these genes are capable of rearrangement in T-cell DNA. When the downstream Cβ2 gene is rearranged, deletion of the Cβ1 gene can occur. These characteristics of rearrangement and deletion of β-chain genes show analogies to the immunoglobulin gene loci.

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