Intracranial Meningeal Tumours in Childhood: A Clinicopathologic Study Including MIB-1 Immunohistochemistry

https://doi.org/10.1016/S0344-0338(00)80095-3Get rights and content

Summary

Primary tumours of the meninges with a relatively high tendency for malignant behaviour are uncommon in childhood. This study concerns 18 cases of meningeal tumours in children under the age of 16, of which 13 were meningiomas and five were other tumours arising in the meninges. Meningiomas showed a preponderance in females as in adult series, and the majority were supratentorial in localisation. The percentage of meningeal tumours and meningiomas among all brain tumours in our centre were 3.72% and 2.69%, respectively. Four out of 13 meningiomas were fibroblastic, four were transitional, one was meningothelial, two were psammomatous and two were papillary meningiomas. Seven (38.8%) out of 18 tumours showed anaplastic features, including two papillary meningiomas, two hemangiopericytomas, one mesenchymal chondrosarcoma, one pleomorphic sarcoma and one anaplastic meningeal tumour. Papillary meningiomas with hemangiopericytoma-like solid areas were seen frequently in our cases (15.3%). Meningoangiomatosis was associated with two meningeal tumours. MIB1 (Ki-67) labelling indices (LIs) ranged between 0% and 13,6% (mean 1.83%) in benign, and between 1% and 20% (mean 7.2%) in malignant tumour, including papillary meningiomas. Mean MIB-1 LIs were 5.61% and 1.14% in non-recurrent and recurrent cases, respectively. MIB-1 LIs showed significant differences between benign and malignant meningeal tumours but no significant correlation either with prognosis or recurrence.

References (53)

  • G Cattoretti et al.

    Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB1 and MIB3) detect proliferating cells in microwave-processed, formalin-fixed paraffin sections

    J Pathol

    (1992)
  • BC Chan et al.

    Intracranial meningiomas in childhood

    Surg Neurol

    (1984)
  • LS Chin et al.

    The standardized assessment of argyrophilic organizer regions in meningeal tumours

    J Neurosurg

    (1991)
  • KR Crone et al.

    Relationship between flow cytometric features and clinical behaviour of meningiomas

    Neurosurgery

    (1988)
  • SK Crouse et al.

    Intracranial meningiomas in childhood and adolescence

    Neurology

    (1972)
  • GS Davidson et al.

    Meningeal tumours of childhood

    Cancer

    (1989)
  • HG Deen et al.

    Clinical and pathological study of meningiomas of the first two decades of life

    J Neurosurg

    (1982)
  • E Demirtaş et al.

    Recurrence of meningiomas versus proliferating cell nuclear antigen (PCNA) positivity and AgNOR counting

    Acta Neurochir (Wien)

    (1996)
  • T Fukushima et al.

    Papillary meningioma with pulmonary metastasis

    J Neurosurg

    (1989)
  • BL Guthrie et al.

    Meningeal hemangiopericytoma: histopatological features, treatment and long-term follow-up of 44 cases

    Neurosurgery

    (1989)
  • DA Herz et al.

    Intracranial meningiomas of infancy, childhood and adolescence

    Child's Brain

    (1980)
  • DW Hsu et al.

    Prognostic significance of proliferative indices in meningiomas

    J Neuropathol Exp Neurol

    (1994)
  • H Inoue et al.

    Clinical pathology of malignant meningiomas

    Acta Neurochir (Wien)

    (1984)
  • D Kabus et al.

    Metastatic meningioma: hemangiopericytoma or angioblastic meningioma

    Am J Surg Pathol

    (1993)
  • E Karamitopoulou et al.

    Ki-67 immunoreactivity in human central nervous system tumours: A study with MIB1 monoclonal antibody on archival material

    Acta Neuropathol

    (1994)
  • P Kleihuwa et al.

    Histological Typing of Tumours of Central Nervous System

  • Cited by (0)

    View full text