Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Flavonoids modulate Comet assay responses to food mutagens in human lymphocytes and sperm
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Investigating the potential protective effects of natural product quercetin against imidacloprid-induced biochemical toxicity and DNA damage in adults rats
2019, Toxicology ReportsCitation Excerpt :The damage of membrane lipids, protein and DNA are the endpoint biomarkers of oxidative stress-inducing toxic effect of pesticides [48]. Quercetin previously studied for its protective effects against DNA damage in human lymphocytes in-vitro or in-vivo ([49–51]. Quercetin prevents oxidant injury and cell death by several mechanisms, such as scavenging free radicals, donating hydrogen compound, quenching singlet oxygen and preventing lipid peroxidation [52] reported that quercetin is capable of protecting human leucocytes against oxidative DNA damage caused by hydrogen peroxide in a dose dependent manner.
DNA damage protection by bulk and nano forms of quercetin in lymphocytes of patients with chronic obstructive pulmonary disease exposed to the food mutagen 2-amino-3-methylimidazo [4,5-f]quinolone (IQ)
2018, Environmental ResearchCitation Excerpt :Flavonoids are important antioxidants and play a significant role in carcinogen deactivation in vivo (Dolara et al., 2005). Flavonoids like quercetin are known to modulate effects of HCAs in human lymphocytes and sperm in vitro (Anderson et al., 1998). The results in this study indicated that quercetin may have a beneficial role in lowering IQ toxicity.
Thyroid dysfunction and testicular redox status
2018, Oxidants, Antioxidants, and Impact of the Oxidative Status in Male ReproductionQuercetin Ameliorate Motility in Frozen-Thawed Turkmen Stallions Sperm
2016, Journal of Equine Veterinary ScienceCitation Excerpt :Quercetin, a well-known flavonoid, has many biological activities including improvement of cardiovascular health, eye diseases, allergic disorders, arthritis, anticarcinogenic, and many more [22]. In addition, it has already been shown to exert beneficial effects against ROS production during sperm processing in several species including the equine [16,38–41]. Flavonoid beneficial effects have been related to diverse properties such as ROS scavenging, oxidase inhibition, metal chelating activity, and protecting against DNA damage.