Vitamin and trace mineral metabolism in medroxyprogesterone acetate users

doi:10.1016/S0010-7824(78)80019-5

Contraception

Volume 18, Issue 3, September 1978, Pages 253-269

https://doi.org/10.1016/S0010-7824(78)80019-5 Get rights and content

Abstract

The effect of one year's continual use of medroxyprogesterone acetate as an injectable contraceptive (150 mg I.M. every 90 days) on vitamin (A, B-carotene, E, B-1, B-2, B-6, oral tryptophan load test, folate and B-12) and trace mineral metabolism (Na, K, Ca, Mg, Cu, Zn and phosphorus) were assessed before and at the 3rd week, 3rd, 6th, 9th and 12th months after initiation of daily treatment with a vitamin-mineral supplement, in 12 non-lactating helathy Thai women.

Neither vitamin nor trace mineral metabolism changed significantly as a result of treatment when compared to the pre-treatment control, suggesting that this form of hormonal contraceptive did not interfere with any of the parameters studied.

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Cited by (10)

A study of adrenal corticol function and its reserve activity in long-acting injectable contraceptive users
1988, Contraception
Adrenal function and its reserve capacity were studied in eighteen healthy non-lactating women who received depot-medroxy-progesterone acetate (DMPA: 9 subjects) and norethisterone enanthate (NET-EN: 9 subjects) as long-acting injectable contraceptives. Methodological assessments included: (i) morning fasting concentration of serum cortisol; (ii) diurnal variation of adrenal corticol activity as evidenced by cortisol concentration in serum, samples taken at 0700 and 1600 hours; (iii) urinary free cortisol excretion; and (iv) cortisol response to insulin-induced hypoglycaemia.
None of these assessments was significantly altered by contraceptive administration. This finding indicates that the subject's ability to release cortisol in response to a stressful situation, as well as to normal day-to-day activity, was not impaired by these contraceptive steroids.
The effect of long-acting injectable contraceptives on carbohydrate metabolism
1985, International Journal of Gynecology and Obstetrics
Carbohydrate metabolism, as assessed by the intravenous glucose tolerance test (i.v.-GTT), was studied in 19 healthy, non-lactating women who received injectable contraceptives containing either medroxyprogesterone acetate (DMPA) (10 subjects) or norethisterone enanthate (Net-En) (9 subjects). Tests were made prior to treatment and at intervals over a period of 15 months thereafter. Results obtained indicate that carbohydrate metabolism is not impaired by either of the two progestogens, and neither pyruvate nor cortisol concentrations changed significantly over the period of observation. However, the insulin release in response to glucose loading underwent interesting alterations during treatment. These abnormalities returned promptly to normal after withdrawal of treatment.
Effects of medroxyprogesterone acetate on serum lipids, protein, glucose tolerance and liver function in Thai women
1980, Contraception
Proteins (total, albumin, globulin and their subfractions), carbohydrate (intravenous glucose tolerance test), lipids (serum cholesterol, triglycerides and phospholipids), and liver function tests (alkaline phosphatase, lactic dehydrogenase and aspartate aminotransferase activities in the serum, bromsulphathalein retention test and serum bilirubin) were studied in 12 non-lactating healthy Thai subjects before, and subsequently at 3 weeks and 3, 6, 9 and 12 months after the initiation of treatment with injectable medroxyprogesterone acetate (150 mg I.M. every 90 days).
Serum protein and lipid levels, and the results of liver function and I.V. glucose tolerance tests, remained unchanged in all subjects throughout the one-year study period. However, a significant and persistent increased insulin level was noted in all subjects, after initiation of the hormone treatment, during the first thirty minutes of intravenous glucose load.
It is concluded that injectable medroxyprogesterone acetate used as a contraceptive agent does not interfere with glucose tolerance, lipid and protein metabolism, and that the liver function remains normal during its administration.
Serum copper and zinc in hormonal contraceptive users
1980, Fertility and Sterility
There has been a growing awareness of possible alterations in the trace element profiles of hormonal contraceptive users and their consequences. A study of serum copper and zinc levels in users of combined estrogen-progestogen contraceptives and in users of injectable progestogen was undertaken. Use of combined estrogen-progestogen contraceptives resulted in a significant decrease in serum zinc levels within 3 days and an increase in serum copper levels within 10 days. In users of combined estrogen-progestogen contraceptives the magnitude and time of occurrence of the decrease in zinc levels and the increase in copper levels was unaltered by chemical composition, dosage, route of administration, and duration of use beyond 3 months. With injectable progestogen (norethindrone enanthate, 20 mg/month), a significant decrease in serum zinc levels occurred within 24 hours after injection. Serum copper levels were not altered. With injectable progestogen, the type of drug, the dosage, and the duration of use beyond the 1st month had no effect on the magnitude of the decrease in serum zinc levels.
Vitamins and oral contraceptives
2017, Vitamins in Human Biology and Medicine
Application of the erythrocyte glutathione reductase test to the evaluation of vitamin B<sup>2</sup> status in normal female subjects and in females taking oral contraceptive agents
2017, Recent Vitamin Research

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^*: Supported in part by the World Health Organization, Geneva.

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Vitamin and trace mineral metabolism in medroxyprogesterone acetate users*

Abstract

J. Biol. Chem.

Amer. J. Clin. Nutr.

Contraception

Lancet

Contraception

Amer. J. Clin. Nutr.

Am. J. Clin. Nutr.

Clin. Chim. Acta.

Contraception

Fert. Steril.

Am. J. Obstet. Gynec.

Conception control by long-acting progestogens: Preliminary Report

Obst-Gynec.

Determination of copper and zinc in biological materials

Clin. Chem.

An improved method for the micro-determination of inorganic phosphates in small volumes of biological fluids

J. Med. Lab. Techn.

Macro- and micromethods for the determination of serum vitamin A using trifluoroacetic acid

J. Nutr.