Conditional ablation of the Notch2 receptor in the ocular lens
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Highlights
► Canonical Notch signaling regulates vertebrate lens growth and differentiation. ► No Notch receptor has been implicated in mouse lens development. ► Notch2 deletion causes excess fiber cells, but no loss of proliferation.► Notch2 mutants have increased apoptosis and defective cell cycle withdrawal.► Notch2 is genetically required to maintain Cdh1 and suppress Cdkn1a expression.
Keywords
Notch2
Lens fiber cell differentiation
Lens development
Jag1
p21Cip1
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