In vivo electroporation improves therapeutic potency of a DNA vaccine targeting hepadnaviral proteins
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Highlights
► First study on DNA electroporation (EP) in chronic hepadnaviral infection model. ► Importantly, DNA EP enhanced viral clearance form sera and livers of DHBV-carriers. ► DNA EP stimulated a multi-specific B-cell response recognizing neutralizing epitopes. ► DNA EP resulted in high expression of intrahepatic IFN-γ of DHBV-carriers. ► First evidence on benefit of DNA EP for chronic hepatitis B therapy.
Keywords
DNA vaccine
DNA electroporation
Hepatitis B virus (HBV)
Duck hepatitis B virus (DHBV)
Hepadnaviruses
Chronic hepatitis B
Immunotherapy
Covalently closed circular DNA (cccDNA)
Interferon-γ
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