OncologyFeasibility and Outcomes of Orthotopic Ileal Neobladder Reconstruction Following Pelvic Irradiation
Section snippets
MATERIAL AND METHODS
Our institutional database was queried for all patients with pT0-4bN0-3M0 urothelial carcinoma who underwent RC with curative intent and ONB between 1990 and 2018. Patients who underwent robotic procedures were not included in this study. We then queried this cohort for patients who had prior pelvic RT for any pelvic malignancy. Only patients with radiation records that could be abstracted from the medical record were included. We limited the patients with prior RT to those that had received
Baseline Characteristics
Of the 2693 patients included in our query, 217 had prior RT. Of those who underwent ONB, 82 of 1846 had prior pelvic RT. We excluded 48 of 82 RT patients that lacked records specifying dose and/or field of radiation or had <3900 cGy directed to the pelvis (Fig. 1). The remaining 34 patients received ≥3900 cGy to the pelvis with a median of 6280 cGy (range, 3910-7910 cGy). RT was directed to the bladder, prostate, and cervix in 27, 6, and 1 patient, respectively, with a median time from
CONCLUSION
This study shows ONB in highly-selected patients with prior pelvic irradiation is feasible with statistically similar perioperative complication rates compared to ONB performed in the setting of no prior radiation. The findings provide reassurance that, when necessary, all reconstructive options are available to patients who decide to undergo bladder-preservation therapy.
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Cited by (2)
Declarations of Interest: None to report.
Financial support: This research did not receive any specific grant from funding agencies in the public, commercial, or non-for-profit sectors. We acknowledge the Norris Cancer Center Support Grant P30 CA014089. There are no financial conflicts of interest.