Oral and maxillofacial pathology
Adenomatoid odontogenic tumors: an analysis of 67 cases in a Thai population

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Objective

The aim of this study was to determine the biologic profile of the adenomatoid odontogenic tumor (AOT) in a Thai population.

Study design

Sixty-seven cases of AOT registered from January 1974 to May 2006 were studied retrospectively. Age, sex, variants of AOT, site and extent of tumors, associated impacted teeth, initial clinical diagnoses, clinical presentations, and duration of symptoms were analyzed.

Results

All AOT cases were intraosseously located, of which 55.2% were follicular and 44.8% extrafollicular. The 2 variants together were found more frequently in the maxilla than in the mandible, with a ratio of 2:1. Females were affected more often than males, with a ratio of 1.8:1. The peak incidence (56.7%) was found in the second decade of life. The majority of AOT lesions (68.7%) was found in the anterior jaws. Adenomatoid odontogenic tumors were observed more often on the left side of jaws (50.7% vs. 38.8%). Canines were the most common teeth associated with follicular AOT (67.5%), and the maxillary canines alone accounted for 51.3% of all cases. The majority of our patients presented with a painless swelling and with duration of symptoms of 6 months and longer.

Conclusions

The distribution and characteristics of AOT in a Thai population are similar to the findings found in other populations. Interestingly, in this series we observed a case involving an impacted deciduous canine and a case associated with an impacted maxillary third molar.

Section snippets

Material and Methods

The histopathologic records of the Department of Oral Pathology, Chulalongkorn University, were reviewed for AOT lesions registered from January 1974 to May 2006. One investigator reevaluated the hematoxylin and eosin stained sections, and the histopathologic diagnosis was made according to the WHO Classification of Tumours.6 Data collected included age, sex, variants of AOT, site and extent of tumors, associated impacted teeth, initial clinical diagnoses, clinical presentations, and duration

Results

The patients were between 6 and 51 years of age at time of diagnosis, with a mean age of 21.1 ± 10.0 years. The mean ages of females and males were not different (20.9 ± 8.3 years and 21.4 ± 12.7 years, respectively; P = .738). The peak incidence of AOT (56.7%) was found in the range of 10 to 19 years of age (Fig. 2).

Of the 1268 cases of odontogenic tumors diagnosed, 67 AOTs were identified (RF = 5.3%). All cases were intraosseous, of which 37 (55.2%) were follicular and 30 (44.8%) were

Discussion

Adenomatoid odontogenic tumor is not a common odontogenic tumor, and it takes time to collect sufficient numbers of representative cases. Therefore, we have only 67 cases on record at the Department of Oral Pathology, Chulalongkorn University, for the past 31 years.

The results of our study agree to a large degree with most studies around the world.9, 16, 17 The RF of AOT among odontogenic tumors in the present study (5.3%) was in the range of previous reports. In comparison with Asian

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