15th Congress of the Asian Society of TransplantationCase reportHigh-Dose Intravenous Immunoglobulin Treatment of Polyomavirus Nephropathy Developing After T Cell–Mediated Rejection Treatment: A Case Report
Section snippets
Case Presentation
A 54-year-old man with a history of hypertension, type 2 diabetes, and continuous ambulatory peritoneal dialysis for 3 years (before kidney transplantation) due to end-stage renal disease underwent kidney transplantation and left nephrectomy on April 22, 2016. He was admitted with an increased serum creatinine level of 2.26 mg/dL (normal range, 1.2–1.4 mg/dL) on June 11, 2016 (postoperative day 50). He had no urinary symptoms. Kidney ultrasound revealed normal echogenicity in the transplanted
Discussion
The present case provides an example of successful treatment using high-dose IVIG in a patient with TCMR and BKVN. There is currently a great deal of controversy about how to treat such cases.
The use of IVIG has a long history in the field of transplantation, and IVIG products are known to have powerful immunomodulatory effects on inflammatory and autoimmune diseases [7]. The rationale of IVIG use in the management of BKVN is based on the potential transfer of protective immunity. The activity
Conclusions
The present case demonstrates that high-dose IVIG therapy can lead to the successful treatment of BKVN after other treatments have failed.
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Cited by (0)
The current study was supported by an Inha University Research Grant.
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The first two authors contributed equally to this work.