Elsevier

Toxicology

Volume 327, 2 January 2015, Pages 95-115
Toxicology

Review
Cross matching observations on toxicological and clinical data for the assessment of tolerability and safety of Ginkgo biloba leaf extract

https://doi.org/10.1016/j.tox.2014.10.013Get rights and content
Under a Creative Commons license
open access

Highlights

  • Cross-matching of toxicological, clinical and other data improves risk analysis.

  • Induction of drug metabolism is linked to increased cell proliferation.

  • Rodents and man have differences in metabolism of Ginkgo biloba.

  • Controlled clinical data did not reveal any serious or specific adverse drug reaction.

  • Cross-matching of various sources gives strong evidence that G. biloba is safe.

Abstract

Ginkgo biloba is one of the most widely used herbal remedies in Europe and the US. It may be purchased in different types of formulations, but most of the clinical studies have been performed with the controlled G. biloba extract EGb761®. Indications include Alzheimers disease, cardiovascular disease, dementia, memory loss, and cerebral ischemia. The pharmacological modes of action cover antioxidant effects, radical scavenging, inhibition of platelet activating factor, alterations in membrane fluidity (signal transduction), and inhibition of glucocorticoid synthesis. Due to the widespread and long-term use of G. biloba – about a million doses of EGb761® are sold per day – tolerability and safety are a crucial issue. Based on broad and long-term clinical use of G. biloba extracts, it is regarded as well tolerated in man.

Cross matching, a tool we introduced, combines different fields of knowledge and types of data to a consolidated result. In this article, we combine toxicological and clinical data and utilize other sources of information to assess tolerability and safety of G. biloba. It is well known that because of biological differences between animals and man or even between animal species, animal experiments do not necessarily mimic the effects in humans. Therefore, for adequate risk assessment, the relevance of non-clinical toxicological findings should be correlated with human data. The cross matching of toxicological data and results from clinical studies is possible because many toxicological and clinical studies are available on G. biloba. We give an in depth analysis of the modes of action in animals and describe toxicological studies with regard to metabolism, pharmacokinetics, genotoxicity, as well as carcinogenicity (e.g., the Technical Report TR 578 of the US National Toxicology Program). In addition, 75 clinical trials with high methodological quality are summarized. They included a total of 7115 patients treated with G. biloba. Based on this extensive amount of information, the broad variety of investigations, and their accordance we conclude that G. biloba extract is well tolerated and safe for humans.

Abbreviations

CYP
cytochrome P-450
GSH-transferase
glutathione-S-transferase
UDP-glucuronosyltransferase
uridine 5′-diphospho-glucuronosyltransferase
EGb761®
Ginkgo biloba extract, CAS 122933-57-7
AhR
aryl hydrocarbon receptor
PXR
pregnane X receptor
CAR
constitutive androstane receptor
ADME
absorption, distribution, metabolism, excretion

Keywords

Cross matching
Ginkgo biloba
EGb761®, CAS 122933-57-7
Carcinogenicity
Adverse drug reaction
Clinical studies

Cited by (0)