ReviewMechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy
Abbreviations
CIPN
cancer chemotherapy-induced peripheral neuropathy
CGRP
calcitonin gene related peptide
cGMP
cyclic guanosine monophosphate
CRPS-I
complex regional pain syndrome
Cyt C
cytochrome C
DRG
dorsal root ganglia
ERK
extracellular signal regulated kinase
IENF
intraepidermal nerve fibers
JNK/Sapk
c-Jun N-terminal kinase/stress-activated protein kinases
LC cells
Langerhans cells
MAPK
mitogen activated protein kinase
mETC
mitochondrial electron transport chain
MMP-3
matrix metalloproteinase-3
mPTP
mitochondrial permeability transition pore
nNOS
neuronal NOS
NMDA
N-methyl-d-aspartate
NR2B
NMDA receptors subtype
PKC
protein kinase C
3PGDH
3-phosphoglycerate dehydrogenase
TREK1
TWIK(Tandem of P domains in a Weak Inward rectifying K+ channel) RElated K+ channels
TRAAK
TWIK related arachidonic acid activated K+ channels
HCNs
hyperpolarization-activated channels
TRPV
transient receptor potential vanilloid
TRPA1
transient receptor potential ankyrin 1
TRPM8
transient receptor potential melastatin 8
Keywords
Cancer-chemotherapeutic drugs
Peripheral neuropathy
Mitochondria
Calcium
Oxidative stress
Inflammation
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