Elsevier

Tetrahedron Letters

Volume 54, Issue 11, 13 March 2013, Pages 1424-1427
Tetrahedron Letters

Novel synthesis of 4,4-difluoropyrido[4,3-b]indoles via intramolecular Heck reaction

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Abstract

Various difluoropyridoindoles were synthesized via a palladium-catalyzed intramolecular Heck reaction as a key step. Thus, ortho-bromoanilines and difluoropiperidinone were treated with (PPh3)2PdCl2 and base in pyridine to give the regioselective cyclized heterocycles in modest to satisfactory yields.

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Acknowledgments

The authors are grateful to the University of Mysore, Mysore for providing laboratory facilities. One of the authors M.M. is thankful to the University of Mysore, Mysore for providing necessary facilities.

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