Boric acid: a novel and safe catalyst for aza-Michael reactions in water

doi:10.1016/j.tetlet.2005.09.167

Tetrahedron Letters

Volume 46, Issue 48, 28 November 2005, Pages 8329-8331

https://doi.org/10.1016/j.tetlet.2005.09.167 Get rights and content

Abstract

Boric acid efficiently catalyzes the conjugate addition of aliphatic amines to α,β-unsaturated compounds to produce β-amino compounds, with great alacrity and excellent yields, in water under mild conditions. Aromatic amines do not participate effectively in the reaction.

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Acknowledgement

S.H. and V.N. thank the Council of Scientific and Industrial Research, New Delhi, India, for research fellowships.

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Boric acid: a novel and safe catalyst for aza-Michael reactions in water

Abstract

Graphical abstract

Section snippets

Acknowledgement

Angew. Chem., Int. Ed.

Synlett

Synlett

Tetrahedon

Tetrahedron Lett.

Acc. Chem. Res.

Adv. Synth. Catal.

ChemBioChem

Chem. Soc. Rev.

J. Med. Chem.

Tetrahedron Lett.

Tetrahedron Lett.

J. Am. Chem. Soc.

J. Org. Chem.

Organometallics