aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1
Under a Creative Commons license
open access
Graphical abstract
Keywords
Gallbladder cancer
Atypical protein kinase Cι
Chemoresistance
Reactive oxygen species
Keap1-Nrf2 pathway
Abbreviations
AJCC
American joint committee on cancer
ARE
antioxidant response element
aPKC
atypical protein kinase C
Bax
Bcl-2-associated X
Bcl2
B-cell lymphoma 2
CCA
Cholangiocarcinoma
CCK-8
Cell Counting Kit-8
Co-IP
Co-Immunoprecipitation
Ect2
Epithelial cell transforming sequence 2
GBC
Gallbladder cancer
IHC
Immunohistochemistry
Keap1
Kelch-like ECH-associated protein 1
Nrf2
Nuclear factor erythroid 2-related factor 2
OS
overall survival
ROS
Reactive oxygen species
Cited by (0)
© 2019 The Authors. Published by Elsevier B.V.