Research PaperCopper–zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma
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Graphical abstract
Keywords
Bortezomib
Copper–zinc superoxide dismutase
Disulfiram
Multiple myeloma
SOD1
Abbreviations
ATN-224
choline tetrathiomolybdate
BR
BTZ resistant
BTZ
bortezomib
CI
confidence interval
Cu
copper
CuZnSOD
copper–zinc superoxide dismutase
DDC
diethyldithiocarbamate
DHE
dihydroethidium
DSF
disulfiram
EFS
event free survival
ER
endoplasmic reticulum
GEP
gene expression profile
GPx
glutathione peroxidase
GSH
glutathione
GSSG
glutathione disulfide
GST
glutathione S-transferase
H2O2
hydrogen peroxide
H2DCF-DA
carboxy-2′,7′-dichlorodihydrofluorescein diacetate
MFI
mean fluorescence intensity
MGUS
monoclonal gammopathy of undetermined significance
MM
multiple myeloma
MnSOD
manganese superoxide dismutase
NAC
N-acetylcysteine
NF-κB
nuclear factor-kappa B
NPC
Normal plasma cells
NSF
normalized survival fraction
PDI
protein disulfide isomerase
PE
plating efficiency
PSMB5
proteasome β5 subunit
O2•−
superoxide
Os
overall survival
ROS
reactive oxygen species
SOD
superoxide dismutase
UPR
unfolded protein response
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Published by Elsevier B.V.